Immunohistochemistry of small blue round cell tumors

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorPhenoPath Laboratories-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorGown, Allen M.-
Autor(es): dc.creatorBacchi, Carlos E.-
Data de aceite: dc.date.accessioned2025-08-21T17:26:33Z-
Data de disponibilização: dc.date.available2025-08-21T17:26:33Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2002-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1179/his.2002.25.4.229-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/224290-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/224290-
Descrição: dc.descriptionSmall blue round cell tumors (SBRCTs) are a set of malignancies that have a particular proclivity for the pediatric age group. These tumors are notoriously difficult to distinguish by histologic evaluation alone, and in recent years a number of new immunohistochemical markers have emerged that can aid in the correct categorization of these lesions. Myogenin, a muscle-restricted nuclear transcription factor, has been demonstrated to be a highly sensitive and specific marker of rhabdomyosarcoma, and is superior to previous markers such as myoglobin, muscle actins, and desmin. The FII-I gene product is expressed as part of the EWS/FLI-1 novel chimeric protein that results from the t(11;22)(q24;q12) translocation that occurs in approximately two-thirds of cases of PNET/Ewings sarcoma. Immunohistochemical detection of the FLI-1 gene product can thus complement detection of CD99/MIC2 for the positive identification of PNET/Ewings sarcoma. Markers of neuroblastoma include neural markers, such as chromogranin A, neurofilaments, and synaptophysin. Desmoplastic small round cell tumor (DSRCT) is a tumor with an unusual immunophenotype, including co-expression of cytokeratin, vimentin, and desmin; recent studies have also documented the use of antibodies to the WT-1 gene product as a marker of the chimeric EWS/WT-1 protein formed as a result of the t(11;22)(p13;q12) translocation that characterizes this unique tumor. In summary, there now exists a panel of antibodies defining immunohistochemical markers of individual SBRCTs that can identify rhabdomyosarcoma, PNET/Ewings sarcoma, neuroblastoma, and DSRCT with high sensitivity and specificity.-
Descrição: dc.descriptionPhenoPath Laboratories, Seattle, WA-
Descrição: dc.descriptionDepartment of Pathology UNESP - Botucatu, Botucatu - SP-
Descrição: dc.descriptionDepartment of Pathology UNESP - Botucatu, Botucatu - SP-
Formato: dc.format229-234-
Idioma: dc.languageen-
Relação: dc.relationJournal of Histotechnology-
???dc.source???: dc.sourceScopus-
Título: dc.titleImmunohistochemistry of small blue round cell tumors-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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