Tetracaine stimulates insulin secretion through the mobilization of Ca2+ from thapsigargin- and IP3-insensitive Ca2+ reservoir in pancreatic β-cells

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorBosqueiro, José Roberto-
Autor(es): dc.creatorCarneiro, Everardo Magalhães-
Autor(es): dc.creatorBordin, Silvana-
Autor(es): dc.creatorBoschero, Antonio Carlos-
Data de aceite: dc.date.accessioned2025-08-21T17:14:34Z-
Data de disponibilização: dc.date.available2025-08-21T17:14:34Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2000-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1139/y00-010-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/224158-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/224158-
Descrição: dc.descriptionThe effect of tetracaine on 45Ca efflux, cytoplasmic Ca2+ concentration [Ca2+](i), and insulin secretion in isolated pancreatic islets and β-cells was studied. In the absence of external Ca2+, tetracaine (0.1-2.0 mM) increased the 45Ca efflux from isolated islets in a dose-dependant manner. Tetracaine did not affect the increase in 45Ca efflux caused by 50 mM K+ or by the association of carbachol (0.2 mM) and 50 mM K+. Tetracaine permanently increased the [Ca2+](i) in isolated β-cells in Ca2+-free medium enriched with 2.8 mM glucose and 25 μM D-600 (methoxiverapamil). This effect was also observed in the presence of 10 mM caffeine or 1 μM thapsigargin. In the presence of 16.7 mM glucose, tetracaine transiently increased the insulin secretion from islets perfused in the absence and presence of external Ca2+. These data indicate that tetracaine mobilises Ca2+ from a thapsigargin-insensitive store and stimulates insulin secretion in the absence of extracellular Ca2+. The increase in 45Ca efflux caused by high concentrations of K+ and by carbachol indicates that tetracaine did not interfere with a cation or inositol triphosphate sensitive Ca2+ pool in β-cells.-
Descrição: dc.descriptionDepartment of Biological Sciences UNESP, Bauru, SP-
Descrição: dc.descriptionDept. of Physiology and Biophysics UNICAMP, Campinas, 13083-970, SP-
Descrição: dc.descriptionDepartment of Biological Sciences UNESP, Bauru, SP-
Formato: dc.format462-468-
Idioma: dc.languageen-
Relação: dc.relationCanadian Journal of Physiology and Pharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCa2+-
Palavras-chave: dc.subjectInsulin secretion-
Palavras-chave: dc.subjectTetracaine-
Palavras-chave: dc.subjectβ-cells-
Título: dc.titleTetracaine stimulates insulin secretion through the mobilization of Ca2+ from thapsigargin- and IP3-insensitive Ca2+ reservoir in pancreatic β-cells-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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