Alterations in myocardial collagen content affect rat papillary muscle function

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorAuburn University-
Autor(es): dc.creatorMatsubara, Luiz S.-
Autor(es): dc.creatorMatsubara, Beatriz B.-
Autor(es): dc.creatorOkoshi, Marina P.-
Autor(es): dc.creatorCicogna, Antonio C.-
Autor(es): dc.creatorJanicki, Joseph S.-
Data de aceite: dc.date.accessioned2025-08-21T17:28:03Z-
Data de disponibilização: dc.date.available2025-08-21T17:28:03Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2000-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1152/ajpheart.2000.279.4.h1534-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/224151-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/224151-
Descrição: dc.descriptionWe investigated the influence of myocardial collagen volume fraction (CVF, %) and hydroxyproline concentration (μg/mg) on rat papillary muscle function. Collagen excess was obtained in 10 rats with unilateral renal ischemia for 5 wk followed by 3-wk treatment with ramipril (20 mg·kg-1·day-1) (RHTR rats; CV-F = 3.83 ± 0.80, hydroxyproline = 3.79 ± 0.50). Collagen degradation was induced by double infusion of oxidized glutathione (GSSG rats; CV-F = 2.45 ± 0.52, hydroxyproline = 2.85 ± 0.18). Nine untreated rats were used as controls (CFV = 3.04 - 0.58, hydroxyproline = 3.21 +- 0.30). Active stiffness (AS; g·cm-2·%L(max)-1) and myocyte cross-sectional area (MA; μm2) were increased in the GSSG rats compared with controls [AS 5.86 vs. 3.96 (P < 0.05); MA 363 ± 59 vs. 305 ± 28 (P < 0.05)]. In GSSG and RHTR groups the passive tension-length curves were shifted downwards, indicating decreased passive stiffness, and upwards, indicating increased passive stiffness, respectively. Decreased collagen content induced by GSSG is related to myocyte hypertrophy, decreased passive stiffness, and increased AS, and increased collagen concentration causes myocardial diastolic dysfunction with no effect on systolic function.-
Descrição: dc.descriptionDepartamento de Clínica Médica Faculdade de Medicina de Botucatu Universidade Estadual Paulista, Botucatu, São Paulo, 18618-000-
Descrição: dc.descriptionDepartment of Anatomy Physiology and Pharmacology Auburn University, Auburn, AL 36849-5517-
Descrição: dc.descriptionDepartamento de Clínica Médica Faculdade de Medicina de Botucatu, 18618-000 Botucatu, São Paulo-
Descrição: dc.descriptionDepartamento de Clínica Médica Faculdade de Medicina de Botucatu Universidade Estadual Paulista, Botucatu, São Paulo, 18618-000-
Descrição: dc.descriptionDepartamento de Clínica Médica Faculdade de Medicina de Botucatu, 18618-000 Botucatu, São Paulo-
Idioma: dc.languageen-
Relação: dc.relationAmerican Journal of Physiology - Heart and Circulatory Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectActive stiffness-
Palavras-chave: dc.subjectFibrosis-
Palavras-chave: dc.subjectOxidized glutathione-
Palavras-chave: dc.subjectPassive stiffness-
Palavras-chave: dc.subjectRenovascular hypertension-
Título: dc.titleAlterations in myocardial collagen content affect rat papillary muscle function-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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