Cholecystokinin actions in the parabrachial nucleus: Effects on thirst and salt appetite

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Iowa-
Autor(es): dc.contributor11 Seashore Hall E-
Autor(es): dc.creatorMenani, Jose Vanderlei-
Autor(es): dc.creatorJohnson, Alan Kim-
Data de aceite: dc.date.accessioned2025-08-21T22:23:58Z-
Data de disponibilização: dc.date.available2025-08-21T22:23:58Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued1998-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1152/ajpregu.1998.275.5.r1431-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/224080-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/224080-
Descrição: dc.descriptionThe present study investigated the effects of bilateral injections of the nonselective CCK receptor antagonist proglumide or CCK-8 into the lateral parabrachial nuclei (LPBN) on the ingestion of 0.3 M NaCl and water induced by intracerebroventricular injection of ANG II or by a combined treatment with subcutaneous furosemide (Furo) + captopril (Cap). Compared with the injection of saline (vehicle), bilateral LPBN injections of proglumide (50 μg · 200 nl-1 · site-1) increased the intake of 0.3 M NaCl induced by intracerebroventricular ANG II (50 ng/l μl). Bilateral injections of proglumide into the LPBN also increased ANG II-induced water intake when NaCl was simultaneously available, but not when only water was present. Similarly, the ingestion of 0.3 M NaCl and water induced by the treatment with Furo (10 mg/kg) + Cap (5 mg/kg) was increased by bilateral LPBN proglumide pretreatment. Bilateral CCK-8 (0.5 μg · 200 nl-1 · site-1) injections into the LPBN did not change Furo + Cap-induced 0.3 M NaCl intake but reduced water consumption. When only water was available after intracerebroventricular ANG II, bilateral LPBN injections of proglumide or CCK-8 had no effect or significantly reduced water intake compared with LPBN vehicle-treated rats. Taken together, these results suggest that CCK actions in the LPBN play a modulatory role on the control of NaCl and water intake induced by experimental treatments that induce hypovolemia and/or hypotension or that mimic those states.-
Descrição: dc.descriptionDepto. de Cie. Fisiológicas Faculdade de Odontologia Paulista State University, Araraquara, SP 14801-903-
Descrição: dc.descriptionDepts. of Psychol. and Pharmacology Cardiovascular Center University of Iowa, Iowa City, IA 52242-1407-
Descrição: dc.descriptionDept. of Psychology Univ. of Iowa 11 Seashore Hall E, Iowa City, IA 52242-1407-
Descrição: dc.descriptionDepto. de Cie. Fisiológicas Faculdade de Odontologia Paulista State University, Araraquara, SP 14801-903-
Idioma: dc.languageen-
Relação: dc.relationAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectProglumide-
Palavras-chave: dc.subjectSodium appetite-
Palavras-chave: dc.subjectSodium chloride intake-
Palavras-chave: dc.subjectWater intake-
Título: dc.titleCholecystokinin actions in the parabrachial nucleus: Effects on thirst and salt appetite-
Tipo de arquivo: dc.typelivro digital-
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