Losartan (DUR-753) blocks the natriuretic, kaliuretic and antidiuretic effect of intracerebroventricular injection of carbachol in water-loaded rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Esladual Paulista-
Autor(es): dc.creatorSaad, William A.-
Autor(es): dc.creatorLuiz, A. C.-
Autor(es): dc.creatorCamargo, L. A.A.-
Autor(es): dc.creatorRenzi, A.-
Autor(es): dc.creatorMenani, J. V.-
Data de aceite: dc.date.accessioned2025-08-21T15:55:12Z-
Data de disponibilização: dc.date.available2025-08-21T15:55:12Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued1996-12-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/224030-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/224030-
Descrição: dc.descriptionWe determined the effect of intracerebroventricular (icv) administration of losartan, an angiotensin II (ANG II) subtype 1 receptor (AT1) antagonist, on icv carbachol-induced natriuresis, kaliuresis and antidiuresis in water-loaded male Holtzman rats (250-300 g) with a cannula implanted into the lateral ventricle (LV). The rats were water loaded with 5% of their body weight by gavage twice, with the second gavage one hour after the first. Carbachol (2 nmol in 1 μl) was injected icv immediately after the second load. When losartan (DUP-753, 50 nmol in 1 μl) was administered icv, it was given 3 min before carbachol. Previous icv treatment with losartan significantly reduced the icv carbachol-induced natriuresis (324 ± 17 μEq/120 min), kaliuresis (103 ± 15 μEq/120min) and antidiuresis (13.5 ± 2.1 ml/120 min) compared to the effects of previous icv injection of saline (Na+ excretion = 498 ± 22 μEq/120 min; K+ excretion = 167 ± 20 μEq/120 min; urine volume = 5.2 ± 1.2 ml/120 min). These results, reported as means ± SEM for 12 rats in each group, are consistent with the hypothesis that AT1 subtype receptors participate in the regulation of body electrolyte balance.-
Descrição: dc.descriptionDepto. de Cie. Fisiológicas Faculdade de Odontotogia Universidade Estadual Paulista, 14801-903 Araraquara, SP-
Descrição: dc.descriptionDepto. de Cie. Fisiológicas Faculdade de Odontologia Universidade Esladual Paulista, Rua Humaitá, 1680, 14801-903 Araraquara, SP-
Descrição: dc.descriptionDepto. de Cie. Fisiológicas Faculdade de Odontotogia Universidade Estadual Paulista, 14801-903 Araraquara, SP-
Formato: dc.format511-513-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Medical and Biological Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAngiotensin II-
Palavras-chave: dc.subjectAT1 receptors-
Palavras-chave: dc.subjectCarbachol-
Palavras-chave: dc.subjectDUP-753-
Palavras-chave: dc.subjectElectrolyte balance-
Palavras-chave: dc.subjectLosartan-
Título: dc.titleLosartan (DUR-753) blocks the natriuretic, kaliuretic and antidiuretic effect of intracerebroventricular injection of carbachol in water-loaded rats-
Tipo de arquivo: dc.typelivro digital-
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