Antagonism of clonidine injected intracerebroventricularly in different models of salt intake

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSato, M. A.-
Autor(es): dc.creatorYada, M. M.-
Autor(es): dc.creatorRenzi, A.-
Autor(es): dc.creatorCamargo, L. A.A.-
Autor(es): dc.creatorSaad, W. A.-
Autor(es): dc.creatorMenani, J. V.-
Autor(es): dc.creatorDe-Luca, L. A.-
Data de aceite: dc.date.accessioned2025-08-21T16:31:37Z-
Data de disponibilização: dc.date.available2025-08-21T16:31:37Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued1996-12-23-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/224027-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/224027-
Descrição: dc.descriptionClonidine, an α2-adrenergic agonist, injected into the brain inhibits salt intake of animals treated by the diuretic model of sodium depletion. In the present study, we address the question of whether central injection of clinidine also inhibits salt intake in amimals deprived of water or in the need-free state. Saline or clonidine (30 nmol) was injected into the anterior third ventricle of 24-h sodium-depleted (furosemide + removal of ambient sodium), of 24-h water-deprived and of normovolemic (need-free state) adult male rats. Clonidine injected intracerebroventricularly (icv) inhibited the 1.5% NaCl intake for 120 min by 50 to 90% in every model tested. Therefore, different models of salt intake are inhibited by icv injection of clinidine. Idazoxan, and α2-adrenergic antagonist, injected icv at a dose of 160 nmol, inhibited the effect of clonidine only in the furosemide + removal of ambient sodium model of salt intake. This indicates that the antagonism of this effect by idazoxan is dependent on the body fluid/sodium status of the animal.-
Descrição: dc.descriptionDepartemento de Ciê. Fisiol. Faculdade de Odontologia Universidade Estadual Paulista, 14801-903 Araraquara, SP-
Descrição: dc.descriptionDepartemento de Ciê. Fisiol. Faculdade de Odontologia Universidade Estadual Paulista, 14801-903 Araraquara, SP-
Formato: dc.format1663-1666-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Medical and Biological Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectadrenoceptors-
Palavras-chave: dc.subjectdehydration-
Palavras-chave: dc.subjectidazoxan-
Palavras-chave: dc.subjectsodium intake-
Título: dc.titleAntagonism of clonidine injected intracerebroventricularly in different models of salt intake-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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