Inhibitory effect of DUP-753 on the drinking responses of rats to central administration of noradrenaline and angiotensin II and to dehydration

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorReis, L. C.-
Autor(es): dc.creatorSaad, William A.-
Autor(es): dc.creatorCamargo, L. A.A.-
Autor(es): dc.creatorRenzi, A.-
Autor(es): dc.creatorMenani, J. V.-
Autor(es): dc.creatorSilveira, J. E.N.-
Data de aceite: dc.date.accessioned2025-08-21T19:49:07Z-
Data de disponibilização: dc.date.available2025-08-21T19:49:07Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued1996-05-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/224025-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/224025-
Descrição: dc.descriptionWe investigated the effect of losartan (DUP-753) on the dipsogenic responses produced by intracerebroventricular (icv) injection of noradrenaline (40 nmol/μl) and angiotensin II (ANG II) (2 ng/μl) in male Holtzman rats weighing 250-300 g. The effect of DUP-753 was also studied in animals submitted to water deprivation for 30 h. After control injections of isotonic saline (0.15 M NaCl, 1 μl) into the lateral ventricle (LV) the water intake was 0.2 ± 0.01 ml/h. DUP-753 (50 nmol/μl) when injected alone into the LV of satiated animals had no significant effect on drinking (0.4 ± 0.02 ml/h) (N = 8). DUP-753 (50 nmol/μl) injected into the LV prior to noradrenaline reduced the water intake from 2.4 ± 0.8 to 0.8 ± 0.2 ml/h (N = 8). The water intake induced by injection of ANG II and water deprivation was also reduced from 9.2 ± 1.4 and 12.7 ± 1.4 ml/h to 0.8 ± 0.2 and 1.7 ± 0.3 ml/h (N = 6 and N = 8), respectively. These data indicate a correlation between noradrenergic pathways and angiotensinergic receptors and lead us to conclude that noradrenaline-induced water intake may be due to the release of ANG II by the brain. The finding that water intake was reduced by DUP-753 in water-deprived animals suggests that dehydration releases ANG II, and that AT1 receptors of the brain play an important role in the regulation of water intake induced by deprivation.-
Descrição: dc.descriptionDepto. de Cie. Fisiológicas Faculdade de Odontologia Universidade Estadual Paulista, 14801-903 Araraquara, SP-
Descrição: dc.descriptionDepto. de Cie. Fisiológicas Faculdade de Odontologia Universidade Estadual Paulista, Rua Humaitá, 1680, 14801-903 Araraquara, SP-
Descrição: dc.descriptionDepto. de Cie. Fisiológicas Faculdade de Odontologia Universidade Estadual Paulista, 14801-903 Araraquara, SP-
Descrição: dc.descriptionDepto. de Cie. Fisiológicas Faculdade de Odontologia Universidade Estadual Paulista, Rua Humaitá, 1680, 14801-903 Araraquara, SP-
Formato: dc.format507-510-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Medical and Biological Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectangiotensin-
Palavras-chave: dc.subjectDUP-753-
Palavras-chave: dc.subjectnoradrenaline-
Palavras-chave: dc.subjectwater intake-
Título: dc.titleInhibitory effect of DUP-753 on the drinking responses of rats to central administration of noradrenaline and angiotensin II and to dehydration-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.