Effect of pancreas transplantation on the prevention of nephropathy in alloxan-induced diabetic rats

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSpadella, C. T.-
Autor(es): dc.creatorMercadante, M. C.S.-
Autor(es): dc.creatorSchellini, S. A.-
Autor(es): dc.creatorMachado, J. L.M.-
Autor(es): dc.creatorOliveira, W. K.-
Autor(es): dc.creatorBacchi, C. E.-
Data de aceite: dc.date.accessioned2025-08-21T22:51:29Z-
Data de disponibilização: dc.date.available2025-08-21T22:51:29Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued1996-08-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/224018-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/224018-
Descrição: dc.descriptionWe studied the effects of pancreas transplantation on kidney lesions of rats with alloxan-induced diabetes. Ninety inbred male Lewis rats were randomly assigned to 3 experimental groups: group NC included 30 non-diabetic control rats, group DC included 30 alloxan-induced diabetic control rats, and group PT included 30 alloxan-induced diabetic rats that received pancreas transplants from normal donor Lewis rats. Each group was further divided into 3 subgroups of 10 rats which were sacrificed at 1, 3, and 6 months of follow-up, respectively. Clinical and laboratory parameters during these periods were documented. The kidneys of 5 rats in each subgroup were studied and 50 glomeruli and tubules from each kidney were analyzed by light microscopy by two different investigators in a double-blind study. There was progressive glomerular basement membrane thickening (GBMT), mesangial enlargement (ME), and Bowman's capsule thickening (BCT) in kidneys of rats in the 3 experimental groups during follow-up. These alterations were significantly higher in DC rats (GBMT: 1.99 ± 0.31; ME: 2.00 ± 0.33; BCT: 1.88 ± 0.27) when compared to NC (GBMT: 1.54 ± 0.30; ME: 1.56 ± 0.47; BCT: 1.36 ± 0.35) and PT rats (GBMT: 1.49 ± 0.29; ME: 1.57 ± 0.36; BCT: 1.35 ± 0.28) at 6 months (P < 0.01). The extent of GBMT, ME, and BCT observed in DC rats at 1 and 3 months was not significantly different from NC and PT rats. The amount of kidney lesions in PT rats was similar to that of NC rats and lower than those of DC rats at 6 months (P < 0.01). In addition, Armanni-Ebstein lesions of the tubules (AE) and tubular lumen protein (PRO) observed in DC rats were not present in NC or PT rats. We conclude that pancreas transplantation in alloxan-induced diabetic rats prevents the development of kidney lesions beginning at 6 months after transplantation.-
Descrição: dc.descriptionDepartamento de Cirurgia e Ortopedia Faculdade de Medicina de Botucatu Universidade Estadual Paulista, 18618-970 Botucatu, SP-
Descrição: dc.descriptionDepto. Oftalmol. O. Faculdade de Medicina de Botucatu Universidade Estadual Paulista, 18618-970 Botucatu, SP-
Descrição: dc.descriptionDepartamento de Patologia Faculdade de Medicina de Botucatu Universidade Estadual Paulista, 18618-970 Botucatu, SP-
Descrição: dc.descriptionDepartamento de Cirurgia e Ortopedia Faculdade de Medicina de Botucatu Universidade Estadual Paulista, 18618-970 Botucatu, SP-
Descrição: dc.descriptionDepto. Oftalmol. O. Faculdade de Medicina de Botucatu Universidade Estadual Paulista, 18618-970 Botucatu, SP-
Descrição: dc.descriptionDepartamento de Patologia Faculdade de Medicina de Botucatu Universidade Estadual Paulista, 18618-970 Botucatu, SP-
Formato: dc.format1019-1024-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Medical and Biological Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectalloxan-induced diabetes-
Palavras-chave: dc.subjectdiabetic nephropathy-
Palavras-chave: dc.subjectpancreas transplantation-
Título: dc.titleEffect of pancreas transplantation on the prevention of nephropathy in alloxan-induced diabetic rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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