Alpha-adrenergic pathways in the lateral hypothalamus are important for the dipsogenic effect of carbachol injected into the medial septal area

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCallera, J. C.-
Autor(es): dc.creatorSaad, W. A.-
Autor(es): dc.creatorCamargo, L. A.A.-
Autor(es): dc.creatorMenani, J. V.-
Autor(es): dc.creatorRenzi, A.-
Autor(es): dc.creatorAbrao-Saad, W.-
Data de aceite: dc.date.accessioned2025-08-21T20:50:52Z-
Data de disponibilização: dc.date.available2025-08-21T20:50:52Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued1995-01-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/224001-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/224001-
Descrição: dc.descriptionWe studied the effect of the α1- and α2-adrenergic receptors of the lateral hypothalamus (LH on the control of water intake induced by injection of carbachol into the medial septal area (MSA) of adult male Holtzman rats (250-300 g) implanted with chronic stainless steel cannulae into the LH and MSA. The volume of injection was always 1 μl and was injected over a period of 30-60 s. For control, 0.15 M NaCl was used. Clonidine (20 nmol) but not phenylephrine (160 nmol) injected into the LH inhibited water intake induced by injection of carbachol (2 nmol) into the MSA, from 5.4 ± l.2 ml/h to 0.3 ± 0.1 and 3.0 ± 0.9 ml/h, respectively (N = 26). When we injected yohimbine (80 nmol) + clonidine (20 nmol) and prazosin (40 nmol) + clonidine (20 nmol) into the LH, water intake induced by injection of carbachol into the MSA was inhibited from 5.4 ± 1.2 ml/h to 0.8 ± 0.5 and 0.3 ± 0.2 ml/h, respectively (N = 19). Water intake induced by carbachol (2 nmol) injected into the MSA was decreased by previous injection of yohimbine (80 nmol) + phenylephrine (160 nmol) and prazosin (40 nmol) + phenylephrine (160 nmol) from 5.4 ± 1.2 ml/h to 1.0 ± 0.7 and 1.8 ± 0.8 ml/h, respectively (N = 16). The cannula reached both the medial septal area in its medial portion and the lateral hypothalamus. It has been suggested that the different pathways for induction of drinking converge on a final common pathway. Thus, adrenergic stimulation of α2-adrenoceptors of LH can influence this final common pathway.-
Descrição: dc.descriptionDpto. de Ciencias Fisiologicas Faculdade de Odontologia UNESP, Rua Humanita, 1680, 14801-903 Araraquara, SP-
Descrição: dc.descriptionDpto. de Ciencias Fisiologicas Faculdade de Odontologia UNESP, Rua Humanita, 1680, 14801-903 Araraquara, SP-
Formato: dc.format240-245-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Medical and Biological Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectα1- and α2-adrenoceptors-
Palavras-chave: dc.subjectcholinergic receptors-
Palavras-chave: dc.subjectlateral hypothalamus-
Palavras-chave: dc.subjectseptal area-
Palavras-chave: dc.subjectwater intake-
Título: dc.titleAlpha-adrenergic pathways in the lateral hypothalamus are important for the dipsogenic effect of carbachol injected into the medial septal area-
Tipo de arquivo: dc.typelivro digital-
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