Atenção:
O eduCAPES é um repositório de objetos educacionais, não sendo responsável por materiais de terceiros submetidos na plataforma. O usuário assume ampla e total responsabilidade quanto à originalidade, à titularidade e ao conteúdo, citações de obras consultadas, referências e outros elementos que fazem parte do material que deseja submeter. Recomendamos que se reporte diretamente ao(s) autor(es), indicando qual parte do material foi considerada imprópria (cite página e parágrafo) e justificando sua denúncia.
Caso seja o autor original de algum material publicado indevidamente ou sem autorização, será necessário que se identifique informando nome completo, CPF e data de nascimento. Caso possua uma decisão judicial para retirada do material, solicitamos que informe o link de acesso ao documento, bem como quaisquer dados necessários ao acesso, no campo abaixo.
Todas as denúncias são sigilosas e sua identidade será preservada. Os campos nome e e-mail são de preenchimento opcional. Porém, ao deixar de informar seu e-mail, um possível retorno será inviabilizado e/ou sua denúncia poderá ser desconsiderada no caso de necessitar de informações complementares.
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (UNESP) | - |
Autor(es): dc.creator | Barretti, P. | - |
Autor(es): dc.creator | Viero, R. M. | - |
Autor(es): dc.creator | Soares, V. A. | - |
Data de aceite: dc.date.accessioned | 2025-08-21T17:43:19Z | - |
Data de disponibilização: dc.date.available | 2025-08-21T17:43:19Z | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 1995-01-01 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/223999 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/223999 | - |
Descrição: dc.description | Adriamycin, a commonly used antineoplastic antibiotic, induces glomerular lesions in rats, resulting in persistent proteinuria and glomerulosclerosis. We studied the effects of dietary protein and of an angiotensin I converting enzyme inhibitor on the progression of this nephropathy and the evolution of the histological lesions, as well as mesangial macromolecule flow. Adriamycin nephropathy was induced by injecting a single iv dose of adriamycin (3 mg/kg body weight) into the tail vein of male Wistar rats (weight, 180-200 g). In Experiment I animals with adriamycin-induced nephropathy were fed diets containing 6% (Low-Protein Diet Group = LPDG), 20% (Normal-Protein Diet Group = NPDG) and 40% (High-Protein Diet Group = HPDG) protein and were observed for 30 weeks. In Experiment II the rats with adriamycin nephropathy were divided into 2 groups: ADR, that received adriamycin alone, and ADR-ENA, that received adriamycin plus enalapril, an angiotensin I converting enzyme inhibitor. The animals were sacrificed after a 24-week observation period. Six hours before sacrifice the animals were injected with 131I-ferritin and the amount of 131I-ferritin in the glomeruli was measured. In Experiment III, renal histology was performed 4, 8 and 16 weeks after adriamycin injection. At the end of Experiment I the tubulointerstitial lesion index was 2 for LPDG, 8 for NPDG, and 7.5 for HPDG (P < 0.05); the frequency of glomerulosclerosis was 19 ± 6.1% in LPDG, 42.6 ± 6% in NPDG, and 54 ± 9% in HPDG (P < 0.05); and proteinuria was 61.1 ± 25 mg/24 h in LPDG, 218.7 ± 27.5 mg/24 h in NPDG, and 324.5 ± 64.8 mg/24 h in HPDG (P < 0.05). In Experiment II, at sacrifice, 24-h proteinuria was 189 ± 16.1 mg in ADR, and 216 ± 26.1 mg in ADR-ENA (P > 0.05); the tubulointerstitial lesion index was 5 for ADR, and 5 for ADR-ENA (P > 0.05); the frequency of glomerulosclerosis was 40 ± 5.2% in ADR and 44 ± 6% in ADR-ENA (P > 0.05); the amount of 131I-ferritin in the mesangium was 214.26 ± 22.71 cpm/mg protein in ADR and 253.77 ± 69.72 cpm/mg protein in ADR-ENA (P > 0.05). In Experiment III, sequential histological analysis revealed an acute tubulointerstitial cellular infiltrate at week 4, which was decreased at week 8. Tubular casts and dilatation were first seen at week 8 and increased at week 16 when few glomerular lesions were found. The results suggest that the tubulointerstitial lesions may play a role in the development of glomerulosclerosis in adriamycin-induced nephropathy. | - |
Descrição: dc.description | Departamento de Clinica Medica Faculdade de Medicina UNESP, 18618-000 Botucatu, SP | - |
Descrição: dc.description | Departamento de Clinica Medica Faculdade de Medicina UNESP, 18618-000 Botucatu, SP | - |
Formato: dc.format | 39-50 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Brazilian Journal of Medical and Biological Research | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | adriamycin nephropathy | - |
Palavras-chave: dc.subject | angiotensin converting enzyme | - |
Palavras-chave: dc.subject | glomerulosclerosis | - |
Palavras-chave: dc.subject | low-protein diet | - |
Palavras-chave: dc.subject | mesangial overload | - |
Título: dc.title | Effects of dietary protein, angiotensin I converting enzyme inhibition and mesangial overload on the progression of adriamycin-induced nephropathy | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: