Injection of ramipril into the lateral ventricle interferes with the drinking response induced by pharmacological and natural thirst stimuli

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSaad, W. A.-
Autor(es): dc.creatorLuiz, A. C.-
Autor(es): dc.creatorCamargo, L. A.A.-
Autor(es): dc.creatorMenani, J. V.-
Autor(es): dc.creatorRenzi, A.-
Autor(es): dc.creatorSilveira, J. E.N.-
Autor(es): dc.creatorPaulino, M. A.-
Data de aceite: dc.date.accessioned2025-08-21T16:56:36Z-
Data de disponibilização: dc.date.available2025-08-21T16:56:36Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued1994-12-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223986-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223986-
Descrição: dc.descriptionWe investigated the effects of ramipril, an angiotensin I-converting enzyme (ACE) inhibitor, on water intake by male Holtzman rats (250-300 g) with cannulae implanted into the lateral ventricle. Intracerebroventricular (icv) injection of ramipril (1 μg/μl) significantly reduced drinking in response to subcutaneous (sc) injection of isoprenaline (100 μg/kg) from 8.49 ± 0.69 to 2.96 ± 0.36 ml/2 h, polyethyleneglycol (PEG) (30% w/v, 10 ml/kg) from 9.51 ± 2.20 to 1.6 ± 0.34 ml/2 h or water deprivation for 24 h from 12.61 ± 0.83 to 5.10 ± 1.37 ml/2 h. Ramipril had no effect on water intake induced by cellular dehydration produced by sc injection of hypertonic saline (2 M NaCl). These results are consistent with the hypothesis that ramipril acts as an ACE-blocking agent in the brain. The possibility that ramipril is transformed to ramiprilat, the active drug, by the brain is suggested.-
Descrição: dc.descriptionDpto. de Ciencias Fisiologicas Faculdade de Odontologia UNESP, Rua Humaita, 1680, 14801-903 Araraquara, SP-
Descrição: dc.descriptionDpto. de Ciencias Fisiologicas Faculdade de Odontologia UNESP, Rua Humaita, 1680, 14801-903 Araraquara, SP-
Formato: dc.format2909-2913-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Medical and Biological Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectangiotensin-
Palavras-chave: dc.subjectcentral nervous system-
Palavras-chave: dc.subjectramipril-
Palavras-chave: dc.subjectwater intake-
Título: dc.titleInjection of ramipril into the lateral ventricle interferes with the drinking response induced by pharmacological and natural thirst stimuli-
Tipo de arquivo: dc.typelivro digital-
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