Antinociceptive effect of amitraz in mice and rats

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorQueiroz-Neto, A.-
Autor(es): dc.creatorJuang, S. J.-
Autor(es): dc.creatorSouza, K. R.-
Autor(es): dc.creatorAkamatsu, A.-
Data de aceite: dc.date.accessioned2025-08-21T23:45:56Z-
Data de disponibilização: dc.date.available2025-08-21T23:45:56Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued1994-01-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223977-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223977-
Descrição: dc.descriptionAmitraz, a formamidine insecticide and acaricide used in veterinary practice, presents side effects related to its pharmacological activity on α2-adrenergic receptors. The present study was undertaken to investigate the antinociceptive effect of amitraz in rats and mice. The tail-flick test was used to determine the duration of the antinociceptive effect of the intraperitoneal (ip) administration of amitraz (1 and 2 mg/kg, 10 animals per group) in male Wistar rats weighing 180-220 g. The writhing test (using 10 ml/kg of a 0.6% acetic acid solution as a painful stimulus) was performed in 140 male Swiss mice weighing 20-30 g, divided into 14 groups that received ip injections of saline, amitraz (0.5, 1.0, 1.5, 2.0 and 4.0 mg/kg), xylazine or detomidine (1.0, 1.5, 2.0 and 4.0 mg/kg), in order to compare the effect of amitraz to that caused by xylazine and detomidine, and to investigate the participation of α2-adrenergic receptors which were blocked by idazoxan (1 mg/kg). Amitraz induced a significant antinociceptive effect in both rats and mice. This effect is blocked in mice by idazoxan.-
Descrição: dc.descriptionDpto. Morfologia/Fisiologia Animal Fac. Ciencias Agrarias/Veterinarias UNESP, 14870-000 Jaboticabal, SP-
Descrição: dc.descriptionDpto. Morfologia/Fisiologia Animal Fac. Ciencias Agrarias/Veterinarias UNESP, 14870-000 Jaboticabal, SP-
Formato: dc.format1407-1411-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Medical and Biological Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectα2-adrenergic agonists-
Palavras-chave: dc.subjectamitraz-
Palavras-chave: dc.subjectantinociceptive effect-
Palavras-chave: dc.subjectdetomidine-
Palavras-chave: dc.subjectidazoxan-
Palavras-chave: dc.subjecttail flick test-
Palavras-chave: dc.subjectwrithing test-
Palavras-chave: dc.subjectxylazine-
Título: dc.titleAntinociceptive effect of amitraz in mice and rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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