Influence of diabetes mellitus on the glutathione redox system of human red blood cells.

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMatsubara, L. S.-
Autor(es): dc.creatorFerreira, A. L.-
Autor(es): dc.creatorTornero, M. T.-
Autor(es): dc.creatorMachado, P. E.-
Data de aceite: dc.date.accessioned2025-08-21T16:52:03Z-
Data de disponibilização: dc.date.available2025-08-21T16:52:03Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued1992-01-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223945-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223945-
Descrição: dc.descriptionSeveral components of the erythrocyte-dependent glutathione redox system (reduced glutathione, GSH; oxidized glutathione, GSSG; glutathione peroxidase, GSH-Px; glutathione reductase, GSH-Red) were determined in patients with types I and II diabetes mellitus (DM). All groups studied were male subjects: G1, 20 young healthy individuals (aged 23.7 +/- 4.2 years); G2, 15 young insulin-treated type I DM patients; G3, 20 older insulin-treated type II DM patients; G4, 21 older oral hypoglycemic agent-treated type II DM patients; G5, 28 aged healthy individuals (aged 68.9 +/- 11.5 years). There were no differences between G1 and G2, G3 or G4 regarding erythrocyte GSH, GSSG, and GSH-Red (without FAD) levels. GSH-Px activity was significantly lower in G2 when compared to G1 (15.2 +/- 4.9 vs 20.6 +/- 6.6 IU/g Hb). The GSH-Red and GSH-Px activities and GSH levels were significantly higher in G3 (4.6 +/- 1.7 IU/g Hb, 20.2 +/- 8.7 IU/g Hb and 3.5 +/- 1.3 microM/g Hb) and G4 (5.0 +/- 2.2 IU/g Hb, 16.9 +/- 6.1 IU/g Hb and 5.0 +/- 2.3 microM/g Hb) when compared to G5 (3.4 +/- 0.9 IU/g Hb, 12.0 +/- 3.6 IU/g Hb and 2.3 +/- 0.9 microM/g Hb). The findings suggest that treatment of DM can stimulate the redox activity of red blood cells in aged subjects.-
Descrição: dc.descriptionDepartamento de Clínica Médica Faculdade de Medicina de Botucatu Universidade Estadual Paulista SP-
Descrição: dc.descriptionDepartamento de Clínica Médica Faculdade de Medicina de Botucatu Universidade Estadual Paulista SP-
Formato: dc.format331-335-
Idioma: dc.languageen-
Relação: dc.relationBrazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas / Sociedade Brasileira de Biofísica ... [et al.]-
???dc.source???: dc.sourceScopus-
Título: dc.titleInfluence of diabetes mellitus on the glutathione redox system of human red blood cells.-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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