Charge effect in the interaction of doxorubicin and derivatives with polydeoxynucleotides

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorInstitute of Biology, Faculty of Medicine, University of Udine-
Autor(es): dc.creatorRuggiero, João-
Autor(es): dc.creatorXodo, Luigi E.-
Autor(es): dc.creatorCiana, Antonio-
Autor(es): dc.creatorManzini, Giorgio-
Autor(es): dc.creatorQuadrifoglio, Franco-
Data de aceite: dc.date.accessioned2025-08-21T23:14:50Z-
Data de disponibilização: dc.date.available2025-08-21T23:14:50Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued1992-02-11-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/0167-4781(92)90506-U-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223933-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223933-
Descrição: dc.descriptionThe equilibrium interaction of doxorubicin and its N-acetyl derivative with a series of purine-pyrimidine alternating polydeoxynucleotides has been studied through spectrofluorometry to assess the relevance of the electrostatic contribution to DNA intercalation. The results have shown that: (a) the suppression of the positive charge on the aminosugar has: (I) a profound negative effect on the free energy of intercalation, as expected, and (II) a negligible influence on the base specificity, which supports the notion of an essentially electrostatic effect of N-acetylation on intercalation; (b) a reasonably good accord with the demands of a polyelectrolytic model, due to Friedman and Manning, is found. © 1992.-
Descrição: dc.descriptionPhysics Department, Institute of Biosciences, UNESP, São José do Rio Preto-
Descrição: dc.descriptionDepartment of Biochemistry, Biophysics and Macromolecular Chemistry, University of Trieste, Trieste-
Descrição: dc.descriptionInstitute of Biology, Faculty of Medicine, University of Udine, Udine-
Descrição: dc.descriptionPhysics Department, Institute of Biosciences, UNESP, São José do Rio Preto-
Formato: dc.format294-302-
Idioma: dc.languageen-
Relação: dc.relationBBA - Gene Structure and Expression-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDoxorubicin-
Palavras-chave: dc.subjectDrug-DNA intercalation-
Palavras-chave: dc.subjectPolyelectrolyte effect-
Título: dc.titleCharge effect in the interaction of doxorubicin and derivatives with polydeoxynucleotides-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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