Induction of micronuclei and toxic effects in embryos of pregnant rats treated before implantation with anticancer drugs: Cyclophosphamide, Cis‐platinum, adriamycin

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Milan-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorSchool of Pharmacy-
Autor(es): dc.creatorGiavini, E.-
Autor(es): dc.creatorLemonica, I. P.-
Autor(es): dc.creatorLou, Y.-
Autor(es): dc.creatorBroccia, M. L.-
Autor(es): dc.creatorPrati, M.-
Data de aceite: dc.date.accessioned2025-08-21T15:28:56Z-
Data de disponibilização: dc.date.available2025-08-21T15:28:56Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued1990-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/tcm.1770100507-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223915-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223915-
Descrição: dc.descriptionTo evaluate a possible relationship of maternal exposure to anticancer drugs during the preimplantation period to blastopathies and postimplantation embryotoxicity, CD female rats were injected intraperitoneally on day 3 of pregnancy with 15 and 30 mg/kg of cyclophosphamide (CPA), 2 and 4 mg/kg of Adriamycin (ADR), 3 and 6 mg/kg of cis‐platinum (Cis‐Pt), or with 5 ml/kg of saline. Blastocysts were collected on day 5 of gestation and evaluated for gross morphology, cell number, and micronuclei. Some females were sacrificed on day 21 of pregnancy in order to evaluate postimplantation embryotoxicity. A reduction in cell number/blastocyst was observed only in animals exposed to Cis‐Pt 6 mg/kg; vice versa, a dose‐related increase of micronuclei and of blastocysts with micronuclei was found in all groups treated with the anticancer agents. A significant increase of postimplantation loss was recorded in the groups treated with high doses of Cis‐Pt and ADR, but no clear signs of teratogenicity were observed. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company-
Descrição: dc.descriptionDepartment of Biology University of Milan, Milan-
Descrição: dc.descriptionDepartment of Pharmacology Ibb Unesp, Botucatu, Sao Paulo-
Descrição: dc.descriptionZhejiang Medical University School of Pharmacy, Hangzhou, Zhejiang-
Descrição: dc.descriptionDepartment of Pharmacology Ibb Unesp, Botucatu, Sao Paulo-
Formato: dc.format417-426-
Idioma: dc.languageen-
Relação: dc.relationTeratogenesis, Carcinogenesis, and Mutagenesis-
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Palavras-chave: dc.subjectblastocyst-
Palavras-chave: dc.subjectembryotoxicity-
Palavras-chave: dc.subjectgenotoxic effects-
Palavras-chave: dc.subjectpreimplantation-
Palavras-chave: dc.subjectteratogenicity-
Título: dc.titleInduction of micronuclei and toxic effects in embryos of pregnant rats treated before implantation with anticancer drugs: Cyclophosphamide, Cis‐platinum, adriamycin-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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