Successful immunotherapy in a murine metastasizing fibrosarcoma model

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorInstituto Nacional de la Nutriclon-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCortes, Ruben-
Autor(es): dc.creatorCorrea, Luis A.-
Autor(es): dc.creatorBehbehani, Abdulla I.-
Autor(es): dc.creatorSonis, Stephen T.-
Autor(es): dc.creatorWilson, Richard E.-
Data de aceite: dc.date.accessioned2025-08-21T18:50:46Z-
Data de disponibilização: dc.date.available2025-08-21T18:50:46Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued1984-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/jso.2930250415-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223904-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223904-
Descrição: dc.descriptionAntigenic differences were demonstrated between the primary murine fibrosarcoma and its metastases. Immunization with irradiated primary tumor cells (TC) protected C57B1/6J mice against subsequent challenge with those cells, but not against challenge with cells from pulmonary metastases (PMC). Mice immunized with irradiated PMC were protected from challenge with those cells, but not against challenge with TC. Mice with fibrosarcomas produced by the injection of 5 × 103 cells from the primary tumor were treated by resection of the tumor‐bearing limb (Amp), Amp plus cylcophosphamide (Amp+Cy), Amp plus primary TC (Amp+TC), Amp plus primary TC and from its metastatic variant (Amp + TC + PMC), and with combinations of the last two groups with Cy. Although Amp+Cy improved survival, no animal lived 100 days and metastases increased as compared to controls. Immunotherapy significantly improved survival and decreased pulmonary metastases. Antigen combinations from primary and metastatic tumors resulted in significantly better survival than did a single preparation only from TC. Chemotherapy did not enhance the results obtained with immunotherapy and surgery. Immunity conferred in long‐term survivors was permanent. Copyright © 1984 Wiley‐Liss, Inc., A Wiley Company-
Descrição: dc.descriptionDepartment of Surgery Brigham and Women's Hospital Instituto Nacional de la Nutriclon, Mexico-
Descrição: dc.descriptionDepartamento de Urologia Faculdade de Medicina de Botucatu-UNESP, Sao Paulo-
Descrição: dc.descriptionDepartamento de Urologia Faculdade de Medicina de Botucatu-UNESP, Sao Paulo-
Formato: dc.format289-295-
Idioma: dc.languageen-
Relação: dc.relationJournal of Surgical Oncology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantigen-
Palavras-chave: dc.subjectfibrosarcoma-
Palavras-chave: dc.subjectimmunotherapy-
Palavras-chave: dc.subjectmurine-
Título: dc.titleSuccessful immunotherapy in a murine metastasizing fibrosarcoma model-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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