Mutagenic and cytotoxic activity of an isocoumarin (paepalantine) isolated from Paepalanthus vellozioides

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorEstadual Paulist University-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Federal de Pernambuco (UFPE)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorVaranda, Eliana Aparecida-
Autor(es): dc.creatorRaddi, Maria Stella Gonçalves-
Autor(es): dc.creatorDe Luz Dias, Francisca-
Autor(es): dc.creatorAraújo, Maria Cristina P.-
Autor(es): dc.creatorGibran, Solange Cardoso Alvares-
Autor(es): dc.creatorTakahashi, Catarina S.-
Autor(es): dc.creatorVilegas, Wagner-
Data de aceite: dc.date.accessioned2025-08-21T21:32:04Z-
Data de disponibilização: dc.date.available2025-08-21T21:32:04Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued1997-09-03-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/(SICI)1520-6866(1997)17:2<85-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223852-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223852-
Descrição: dc.descriptionA new isocoumarin with antimicrobial activity was isolated from Paepalanthus vellozioides (a native Brazilian plant) and called paepalantine. This study was carried out to assess the mutagenic activity of this new agent in assays with Salmonella typhimurium TA100, TA98, and TA102 and in Chinese hamster ovary (CHO) cell cultures, as well as cytotoxicity to McCoy cells. Paepalantine caused a significant dose-dependent increase in the frequency of revertants in the three strains used in the assay, both with and without S9 mix, in concentrations varying from 2 to 128 μg/plate. The mutagenicity was confirmed in assays with CHO cells treated in the G1, S, and G2 phases of the cell cycle. There was an increase in the chromosomal aberration frequency, mainly in the G2 phase. Furthermore, the mitotic index of the treated cultures (40, 80, and 160 μg/ml) was significantly lower, indicating cytotoxicity. The midpoint cytotoxicity values to McCoy cells by the neutral red (NR) and microculture tetrazolium (MTT) techniques resulted in a NR50 and MTT50 of 30 and 38 μg/ml, respectively. Alterations to the paepalantine structure are suggested to reduce its mutagenic and cytotoxic activity in investigations for its antineoplasic potential.-
Descrição: dc.descriptionFac. Pharmaceutical Sci. Araraquara Estadual Paulist University, São Paulo-
Descrição: dc.descriptionFac. of Med. of Ribeirão Preto São Paulo University, São Paulo-
Descrição: dc.descriptionFac. Philos., Sci., Letters R. São Paulo University, São Paulo-
Descrição: dc.descriptionDepartment of Genetics Federal University of Pernambuco, Pernambuco-
Descrição: dc.descriptionChemical Institute of Araraquara Estadual Paulist University, São Paulo-
Descrição: dc.descriptionFaculdade de Cie. Farmaceuticas UNESP Depto. de Cie. Biológicas, Rodovia Araraquara-Jaú. Km 1, CEP 14801-9O2, Araraquara, Sao Paulo-
Descrição: dc.descriptionFaculdade de Cie. Farmaceuticas UNESP Depto. de Cie. Biológicas, Rodovia Araraquara-Jaú. Km 1, CEP 14801-9O2, Araraquara, Sao Paulo-
Formato: dc.format85-95-
Idioma: dc.languageen-
Relação: dc.relationTeratogenesis Carcinogenesis and Mutagenesis-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAmes test-
Palavras-chave: dc.subjectChromosomal aberrations-
Palavras-chave: dc.subjectCytotoxicity-
Palavras-chave: dc.subjectIsocoumarin-
Palavras-chave: dc.subjectPaepalantine-
Título: dc.titleMutagenic and cytotoxic activity of an isocoumarin (paepalantine) isolated from Paepalanthus vellozioides-
Tipo de arquivo: dc.typelivro digital-
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