Eculizumab in low-middle income countries: how much does a life cost?

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorHospital Beneficência Portuguesa de São Paulo-
Autor(es): dc.creatorNga, Hong Si-
Autor(es): dc.creatorPalma, Lilian Monteiro Pereira-
Autor(es): dc.creatorErnandes Neto, Miguel-
Autor(es): dc.creatorModelli de Andrade, Luis Gustavo-
Data de aceite: dc.date.accessioned2025-08-21T15:20:13Z-
Data de disponibilização: dc.date.available2025-08-21T15:20:13Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s40620-022-01282-4-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223766-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223766-
Descrição: dc.descriptionAtypical hemolytic uremic syndrome (aHUS) is an ultra-rare disease and eculizumab was approved as first line therapy in 2011 by the Food and Drug Administration. Access to eculizumab in low-middle income countries is challenging. We discuss access to eculizumab in Brazil that was made possible by judicialization or compassionate use. We showed a nationwide cohort of unplanned eculizumab interruptions resulted in higher rates of aHUS relapse. Similar to the French cohort, the use of eculizumab after transplantation showed superior graft survival compared to conventional treatment. We speculate a possible solution to the higher cost of eculizumab in which the government negotiates with the manufacturers. In this process, the government should compromise to ensure validated protocols of drug use, and the pharmaceutical companies, on the other hand, should reduce prices, especially in low-income countries. We also suggest a price adjustment based on gross domestic product.-
Descrição: dc.descriptionDepartment of Internal Medicine UNESP Universidade Estadual Paulista, Av. Prof. Montenegro - Distrito de, SP-
Descrição: dc.descriptionDepartamento de Pediatria/Hospital de Clínicas Universidade Estadual de Campinas, SP-
Descrição: dc.descriptionHospital Beneficência Portuguesa de São Paulo, SP-
Descrição: dc.descriptionDepartment of Internal Medicine UNESP Universidade Estadual Paulista, Av. Prof. Montenegro - Distrito de, SP-
Idioma: dc.languageen-
Relação: dc.relationJournal of Nephrology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAtypical hemolytic uremic syndrome-
Palavras-chave: dc.subjectEculizumab-
Palavras-chave: dc.subjectLow-middle income countries-
Título: dc.titleEculizumab in low-middle income countries: how much does a life cost?-
Tipo de arquivo: dc.typetexto-
Aparece nas coleções:Repositório Institucional - Unesp

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