Concurrent Training Increases Serum Brain-Derived Neurotrophic Factor in Older Adults Regardless of the Exercise Frequency

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Autor(es): dc.contributorUniversidad Autónoma de Baja California-
Autor(es): dc.contributorUniversity of Kansas-
Autor(es): dc.contributorUniversity of Costa Rica-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorDavis-
Autor(es): dc.creatorCanton-Martínez, Ermilo-
Autor(es): dc.creatorRentería, Iván-
Autor(es): dc.creatorGarcía-Suárez, Patricia C.-
Autor(es): dc.creatorMoncada-Jiménez, José-
Autor(es): dc.creatorMachado-Parra, Juan Pablo-
Autor(es): dc.creatorLira, Fabio Santos-
Autor(es): dc.creatorJohnson, David K.-
Autor(es): dc.creatorJiménez-Maldonado, Alberto-
Data de aceite: dc.date.accessioned2025-08-21T21:35:59Z-
Data de disponibilização: dc.date.available2025-08-21T21:35:59Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-03-07-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fnagi.2022.791698-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223729-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223729-
Descrição: dc.descriptionBackground: Human brain function declines with aging. In this sense, exercise-based interventions has a promising effect on brain plasticity for older adults. Serum brain-derived neurotrophic factor (BDNF) is a positive biomarker for brain neuroplasticity in healthy older adults also modified by exercise training. Selected features of the exercise prescription for improving brain health are missing; therefore, the aim of this study was to determine the effects of concurrent exercise training frequency on serum BDNF levels in healthy older adults. Methods: Nineteen volunteers (age: 65 ± 4 year; body mass index: 28.0 ± 4.5 kg/m2) completed either a three times/week (3-t/w) (n = 8) or five times/week (5-t/w) (n = 11) concurrent exercise program. The exercise program lasted 11 weeks and all exercise sessions were performed for 50 min at moderate intensity. Serum BDNF, body composition, cardiovascular, and physical fitness variables were assessed before and after the exercise training program. Results: Regardless of the group, the serum BDNF increased following the intervention (p < 0.001), and there were no significant group (p = 0.827) or interaction (p = 0.063) effects. The maximal oxygen consumption (VO2max) increased regardless of the group (p = 0.007), with a non-significant group (p = 0.722) or interaction (p = 0.223) effects. Upper- and lower-body strength increased in both groups (p = 0.003); however, there was no effect of the training frequency (p = 0.53). For the skeletal muscle mass, there was a trend in the interaction effect (p = 0.053). Finally, the body fat percentage was unchanged. Conclusion: Eleven weeks of combined exercise training increased serum BDNF levels in healthy older adults, a response independent of the training frequency. The overall fitness level improved similarly in both exercise groups. These data reveal that a minimal dosage of concurrent exercise enhance functional capacity and a brain health biomarker in older adults.-
Descrição: dc.descriptionFacultad de Deportes Universidad Autónoma de Baja California-
Descrição: dc.descriptionDepartment of Health Sports and Exercise Sciences University of Kansas-
Descrição: dc.descriptionHuman Movement Sciences Research Center (CIMOHU) University of Costa Rica-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Department of Physical Education Paulista State University UNESP-
Descrição: dc.descriptionDepartment of Neurology University of California Davis-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Department of Physical Education Paulista State University UNESP-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Aging Neuroscience-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbody fat-
Palavras-chave: dc.subjectbrain derived neurotrophic factor-
Palavras-chave: dc.subjectconcurrent training-
Palavras-chave: dc.subjectelderly-
Palavras-chave: dc.subjectheart rate-
Título: dc.titleConcurrent Training Increases Serum Brain-Derived Neurotrophic Factor in Older Adults Regardless of the Exercise Frequency-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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