Nyssorhynchus darlingi genome-wide studies related to microgeographic dispersion and blood-seeking behavior

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de Brasília (UnB)-
Autor(es): dc.contributorUniversidad Peruana Cayetano Heredia-
Autor(es): dc.contributorLondon School of Hygiene and Tropical Medicine-
Autor(es): dc.contributorYale School of Medicine-
Autor(es): dc.contributorNew York State Department of Health-
Autor(es): dc.contributorState University of New York at Albany-
Autor(es): dc.creatorAlvarez, Marcus Vinicius Niz-
Autor(es): dc.creatorAlonso, Diego Peres-
Autor(es): dc.creatorKadri, Samir Moura-
Autor(es): dc.creatorRufalco-Moutinho, Paulo-
Autor(es): dc.creatorBernardes, Isabella Ariadne Ferrari-
Autor(es): dc.creatorde Mello, Ana Carolina Florindo-
Autor(es): dc.creatorSouto, Ana Carolina-
Autor(es): dc.creatorCarrasco-Escobar, Gabriel-
Autor(es): dc.creatorMoreno, Marta-
Autor(es): dc.creatorGamboa, Dionicia-
Autor(es): dc.creatorVinetz, Joseph M.-
Autor(es): dc.creatorConn, Jan E.-
Autor(es): dc.creatorRibolla, Paulo E. M.-
Data de aceite: dc.date.accessioned2025-08-21T17:58:16Z-
Data de disponibilização: dc.date.available2025-08-21T17:58:16Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s13071-022-05219-5-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223726-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223726-
Descrição: dc.descriptionBackground: In Brazil, malaria is concentrated in the Amazon Basin, where more than 99% of the annual cases are reported. The main goal of this study was to investigate the population structure and genetic association of the biting behavior of Nyssorhynchus (also known as Anopheles) darlingi, the major malaria vector in the Amazon region of Brazil, using low-coverage genomic sequencing data. Methods: Samples were collected in the municipality of Mâncio Lima, Acre state, Brazil between 2016 and 2017. Different approaches using genotype imputation and no gene imputation for data treatment and low-coverage sequencing genotyping were performed. After the samples were genotyped, population stratification analysis was performed. Results: Weak but statistically significant stratification signatures were identified between subpopulations separated by distances of approximately 2–3 km. Genome-wide association studies (GWAS) were performed to compare indoor/outdoor biting behavior and blood-seeking at dusk/dawn. A statistically significant association was observed between biting behavior and single nucleotide polymorphism (SNP) markers adjacent to the gene associated with cytochrome P450 (CYP) 4H14, which is associated with insecticide resistance. A statistically significant association between blood-seeking periodicity and SNP markers adjacent to genes associated with the circadian cycle was also observed. Conclusion: The data presented here suggest that low-coverage whole-genome sequencing with adequate processing is a powerful tool to genetically characterize vector populations at a microgeographic scale in malaria transmission areas, as well as for use in GWAS. Female mosquitoes entering houses to take a blood meal may be related to a specific CYP4H14 allele, and female timing of blood-seeking is related to circadian rhythm genes. Graphical Abstract: [Figure not available: see fulltext.]-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionFogarty International Center-
Descrição: dc.descriptionSao Paulo State University (UNESP)-
Descrição: dc.descriptionNucleo de Medicina Tropical Universidade de Brasília-
Descrição: dc.descriptionLaboratorio ICEMR-Amazonia Laboratorios de Investigación Y Desarrollo Facultad de Ciencias Y Filosofia Universidad Peruana Cayetano Heredia-
Descrição: dc.descriptionFacultad de Salud Pública Universidad Peruana Cayetano Heredia-
Descrição: dc.descriptionDepartment of Immunology and Infection London School of Hygiene and Tropical Medicine-
Descrição: dc.descriptionDepartamento de Ciencias Celulares Y Moleculares Facultad de Ciencias Y Filosofía Universidad Peruana Cayetano Heredia-
Descrição: dc.descriptionInstituto de Medicina Tropical Alexander Von Humboldt Universidad Peruana Cayetano Heredia-
Descrição: dc.descriptionSection of Infectious Diseases Department of Internal Medicine Yale School of Medicine-
Descrição: dc.descriptionWadsworth Center New York State Department of Health-
Descrição: dc.descriptionDepartment of Biomedical Sciences School of Public Health State University of New York at Albany-
Descrição: dc.descriptionSao Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2018/07406-6-
Descrição: dc.descriptionFogarty International Center: D43 TW007120-
Idioma: dc.languageen-
Relação: dc.relationParasites and Vectors-
???dc.source???: dc.sourceScopus-
Título: dc.titleNyssorhynchus darlingi genome-wide studies related to microgeographic dispersion and blood-seeking behavior-
Tipo de arquivo: dc.typelivro digital-
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