Extracellular matrix-derived and low-cost proteins to improve polyurethane-based scaffolds for vascular grafts

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorRodrigues, Isabella C. P.-
Autor(es): dc.creatorLopes, Éder S. N.-
Autor(es): dc.creatorPereira, Karina D.-
Autor(es): dc.creatorHuber, Stephany C.-
Autor(es): dc.creatorJardini, André Luiz-
Autor(es): dc.creatorAnnichino-Bizzacchi, Joyce M.-
Autor(es): dc.creatorLuchessi, Augusto D.-
Autor(es): dc.creatorGabriel, Laís P.-
Data de aceite: dc.date.accessioned2025-08-21T18:30:27Z-
Data de disponibilização: dc.date.available2025-08-21T18:30:27Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-022-09040-z-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223724-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223724-
Descrição: dc.descriptionVascular graft surgeries are often conducted in trauma cases, which has increased the demand for scaffolds with good biocompatibility profiles. Biodegradable scaffolds resembling the extracellular matrix (ECM) of blood vessels are promising vascular graft materials. In the present study, polyurethane (PU) was blended with ECM proteins collagen and elastin (Col-El) and gelatin (Gel) to produce fibrous scaffolds by using the rotary jet spinning (RJS) technique, and their effects on in vitro properties were evaluated. Morphological and structural characterization of the scaffolds was performed using scanning electron microscopy (SEM) and atomic force microscopy (AFM). Micrometric fibers with nanometric rugosity were obtained. Col-El and Gel reduced the mechanical strength and increased the hydrophilicity and degradation rates of PU. No platelet adhesion or activation was observed. The addition of proteins to the PU blend increased the viability, adhesion, and proliferation of human umbilical vein endothelial cells (HUVECs). Therefore, PU-Col-El and PU-Gel scaffolds are promising biomaterials for vascular graft applications.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSchool of Applied Sciences University of Campinas, Rua Pedro Zaccaria, 1300, SP-
Descrição: dc.descriptionSchool of Mechanical Engineering University of Campinas, Rua Mendeley, 200, SP-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University, SP-
Descrição: dc.descriptionHematology and Hemotherapy Center University of Campinas, SP-
Descrição: dc.descriptionSchool of Chemical Engineering University of Campinas, SP-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University, SP-
Descrição: dc.descriptionFAPESP: #2017/13273-6-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleExtracellular matrix-derived and low-cost proteins to improve polyurethane-based scaffolds for vascular grafts-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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