Long-Term Clearance and Biodistribution of Magnetic Nanoparticles Assessed by AC Biosusceptometry

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorSoares, Guilherme A.-
Autor(es): dc.creatorFaria, João V. C.-
Autor(es): dc.creatorPinto, Leonardo A.-
Autor(es): dc.creatorProspero, Andre G.-
Autor(es): dc.creatorPereira, Gabriele M.-
Autor(es): dc.creatorStoppa, Erick G.-
Autor(es): dc.creatorBuranello, Lais P.-
Autor(es): dc.creatorBakuzis, Andris F.-
Autor(es): dc.creatorBaffa, Oswaldo-
Autor(es): dc.creatorMiranda, José R. A.-
Data de aceite: dc.date.accessioned2025-08-21T22:08:21Z-
Data de disponibilização: dc.date.available2025-08-21T22:08:21Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ma15062121-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223688-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223688-
Descrição: dc.descriptionOnce administered in an organism, the physiological parameters of magnetic nanoparticles (MNPs) must be addressed, as well as their possible interactions and retention and elimination profiles. Alternating current biosusceptometry (ACB) is a biomagnetic detection system used to detect and quantify MNPs. The aims of this study were to evaluate the biodistribution and clearance of MNPs profiles through long-time in vivo analysis and determine the elimination time carried out by the association between the ACB system and MnFe2O4 nanoparticles. The liver, lung, spleen, kidneys, and heart and a blood sample were collected for biodistribution analysis and, for elimination analysis, and over 60 days. During the period analyzed, the animal’s feces were also collectedd. It was possible to notice a higher uptake by the liver and the spleen due to their characteristics of retention and uptake. In 60 days, we observed an absence of MNPs in the spleen and a significant decay in the liver. We also determined the MNPs’ half-life through the liver and the spleen elimination. The data indicated a concentration decay profile over the 60 days, which suggests that, in addition to elimination via feces, there is an endogenous mechanism of metabolization or possible agglomeration of MNPs, resulting in loss of ACB signal intensity.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences São Paulo State University—UNESP, SP-
Descrição: dc.descriptionInstitute of Physics Federal University of Goiás, GO-
Descrição: dc.descriptionFaculty of Philosophy Sciences and Letters at Ribeirão Preto University of São Paulo, SP-
Descrição: dc.descriptionDepartment of Biophysics and Pharmacology Institute of Biosciences São Paulo State University—UNESP, SP-
Descrição: dc.descriptionFAPESP: 2013/03258-9-
Descrição: dc.descriptionFAPESP: 2015/1492.3-9-
Descrição: dc.descriptionCNPq: 304107/2019-0-
Descrição: dc.descriptionCNPq: 312074/2018-9-
Descrição: dc.descriptionCAPES: 88882.432964/2019-01-
Idioma: dc.languageen-
Relação: dc.relationMaterials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAlternate current biosusceptometry-
Palavras-chave: dc.subjectBiodistribution-
Palavras-chave: dc.subjectClearance-
Palavras-chave: dc.subjectLong-time analysis-
Palavras-chave: dc.subjectMagnetic nanoparticles-
Título: dc.titleLong-Term Clearance and Biodistribution of Magnetic Nanoparticles Assessed by AC Biosusceptometry-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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