Potentially carcinogenic effects of hydrogen peroxide for tooth bleaching on the oral mucosa: A systematic review and meta-analysis

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidad de la República (UDELAR)-
Autor(es): dc.contributorUniversidade Federal do Rio Grande do Sul (UFRGS)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversity of Sheffield (UoS)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSilveira, Felipe Martins-
Autor(es): dc.creatorSchuch, Lauren Frenzel-
Autor(es): dc.creatorSchimidt, Tuany Rafaeli-
Autor(es): dc.creatorLopes, Marina Paparotto-
Autor(es): dc.creatorWagner, Vivian Petersen-
Autor(es): dc.creatorSó, Bruna Barcelos-
Autor(es): dc.creatorPalo, Renato Miotto-
Autor(es): dc.creatorMartins, Manoela Domingues-
Data de aceite: dc.date.accessioned2025-08-21T22:43:56Z-
Data de disponibilização: dc.date.available2025-08-21T22:43:56Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.prosdent.2022.02.001-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223613-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223613-
Descrição: dc.descriptionStatement of problem: Little is known about the extent to which hydrogen peroxide as used for tooth bleaching could be carcinogenic to the oral mucosa. Purpose: The purpose of this systematic review and meta-analysis was to evaluate whether hydrogen peroxide as used for tooth bleaching has carcinogenic effects on the oral mucosa. Material and methods: PubMed, Web of Science, Scopus, and Embase electronic databases were searched. Studies evaluating different outcomes potentially related to the carcinogenic effects of hydrogen peroxide for tooth bleaching on the oral mucosa were included. Risk of bias was assessed by the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE), Risk Of Bias in Non-randomized Studies of Interventions (ROBINS-I), or Risk of Bias 2 (RoB 2) tools. The strength of the evidence was assessed by using the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) protocol. The quantitative analysis was performed with means, standard deviations, and 95% confidence intervals (CIs). Heterogeneity was analyzed by using I-squared statistics. Results: Thirteen articles comprising 5 animal and 8 clinical studies met the inclusion criteria. Three of the 5 animal studies associated the bleaching agents with a carcinogen and demonstrated an enhancement of the carcinogenic effect, but probably with the bleaching agent acting only as a promoter. Five clinical studies concluded that the bleaching agents did not cause mutagenic stress on the oral mucosa by using the micronucleus test. The meta-analysis demonstrated that the frequency of micronuclei did not differ significantly between baseline and 30 days after bleaching (mean difference: 0.48; 95% CI, -1.49, 2.46; P=.63). Conclusions: This systematic review indicated that hydrogen peroxide does not appear to have carcinogenic effects on the oral mucosa.-
Descrição: dc.descriptionAdjunct Professor Molecular Pathology Area School of Dentistry Universidad de la República (UDELAR)-
Descrição: dc.descriptionPost-dotoral Fellowship Department of Oral Pathology School of Dentistry Universidade Federal do Rio Grande do Sul (UFRGS), RS-
Descrição: dc.descriptionPhD student Department of Oral Diagnosis Piracicaba Dental School Universidade Estadual de Campinas (UNICAMP), São Paulo-
Descrição: dc.descriptionPhD student Department of Oral Pathology School of Dentistry Universidade Federal do Rio Grande do Sul (UFRGS), Rio Grande do Sul-
Descrição: dc.descriptionUndergraduate student Department of Oral Diagnosis Piracicaba Dental School Universidade Estadual de Campinas (UNICAMP), São Paulo-
Descrição: dc.descriptionPost-doctoral Fellowship Oral and Maxillofacial Pathology Department of Clinical Dentistry University of Sheffield (UoS)-
Descrição: dc.descriptionPhD in Endodontics Institute of Science and Technology Department of Restorative Dentistry São Paulo State University (UNESP), São Paulo-
Descrição: dc.descriptionAssociate Professor Department of Oral Pathology School of Dentistry Universidade Federal do Rio Grande do Sul (UFRGS), Rio Grande do Sul-
Descrição: dc.descriptionPostgraduation Professor Department of Oral Diagnosis Piracicaba Dental School Campinas State University (UNICAMP), São Paulo-
Descrição: dc.descriptionPhD in Endodontics Institute of Science and Technology Department of Restorative Dentistry São Paulo State University (UNESP), São Paulo-
Idioma: dc.languageen-
Relação: dc.relationJournal of Prosthetic Dentistry-
???dc.source???: dc.sourceScopus-
Título: dc.titlePotentially carcinogenic effects of hydrogen peroxide for tooth bleaching on the oral mucosa: A systematic review and meta-analysis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.