The Dysfunctional Scenario of the Major Components Responsible for Myocardial Calcium Balance in Heart Failure Induced by Aortic Stenosis

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal do Espírito Santo (UFES)-
Autor(es): dc.creatorda Silva, Vitor Loureiro-
Autor(es): dc.creatorde Souza, Sérgio Luiz Borges-
Autor(es): dc.creatorMota, Gustavo Augusto Ferreira-
Autor(es): dc.creatorCampos, Dijon H. S.-
Autor(es): dc.creatorMelo, Alexandre Barroso-
Autor(es): dc.creatorVileigas, Danielle Fernandes-
Autor(es): dc.creatorSant’ana, Paula Grippa-
Autor(es): dc.creatorCoelho, Priscila Murucci-
Autor(es): dc.creatorBazan, Silméia Garcia Zanati-
Autor(es): dc.creatorLeopoldo, André Soares-
Autor(es): dc.creatorCicogna, Antônio Carlos-
Data de aceite: dc.date.accessioned2025-08-21T17:28:24Z-
Data de disponibilização: dc.date.available2025-08-21T17:28:24Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.36660/abc.20200618-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223604-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223604-
Descrição: dc.descriptionBackground: Maladaptive cardiac remodelling is characterized by diastolic and systolic dysfunction, culminating in heart failure. In this context, the dysfunctional scenario of cardiac calcium (Ca2+) handling has been poorly studied. An experimental model of aortic stenosis has been extensively used to improve knowledge about the key mechanisms of cardiac pathologic remodelling. Objective: To understand the dysfunctional process of the major components responsible for Ca2+ balance and its influence on cardiac function in heart failure induced by aortic stenosis. Methods: Male 21-day-old Wistar rats were distributed into two groups: control (sham; n= 28) and aortic stenosis (AoS; n= 18). Cardiac function was analysed by echocardiogram, isolated papillary muscle, and isolated cardiomyocytes. In the papillary muscle assay, SERCA2a and L-type Ca2+ channel activity was evaluated. The isolated cardiomyocyte assay evaluated Ca2+ handling. Ca2+ handling protein expression was analysed by western blot. Statistical significance was set at p <0.05. Results: Papillary muscles and cardiomyocytes from AoS hearts displayed mechanical malfunction. AoS rats presented a slower time to the Ca2+ peak, reduced Ca2+ myofilament sensitivity, impaired sarcoplasmic reticulum Ca2+ influx and reuptake ability, and SERCA2a and L-type calcium channel (LTCC) dysfunction. Moreover, AoS animals presented increased expression of SERCA2a, LTCCs, and the Na+/Ca2+ exchanger. Conclusion: Systolic and diastolic heart failure due to supravalvular aortic stenosis was paralleled by impairment of cellular Ca2+ influx and inhibition of sarcoplasmic reticulum Ca2+ reuptake due to LTCC and SERCA2a dysfunction, as well as changes in Ca2+ handling and expression of the major proteins responsible for cellular Ca2+ homeostasis.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniversidade de São Paulo Departamento de Medicina Interna, SP-
Descrição: dc.descriptionUniversidade Estadual Paulista-Clínica Médica, SP-
Descrição: dc.descriptionUniversidade Federal do Espírito Santo Departamento de Desportos, ES-
Descrição: dc.descriptionUniversidade Estadual Paulista-Clínica Médica, SP-
Descrição: dc.descriptionFAPESP: 2015/20013-5-
Formato: dc.format464-475-
Idioma: dc.languageen-
Relação: dc.relationArquivos Brasileiros de Cardiologia-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAortic stenosis-
Palavras-chave: dc.subjectCalcium handling proteins-
Palavras-chave: dc.subjectHeart failure-
Palavras-chave: dc.subjectIsolated cardiomyocytes-
Palavras-chave: dc.subjectPapillary muscle-
Título: dc.titleThe Dysfunctional Scenario of the Major Components Responsible for Myocardial Calcium Balance in Heart Failure Induced by Aortic Stenosis-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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