Cardiovascular Reactivity to a Novel Stressor: Differences on Susceptible and Resilient Rats to Social Defeat Stress

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMorais-Silva, Gessynger-
Autor(es): dc.creatorGomes-de-Souza, Lucas-
Autor(es): dc.creatorCosta-Ferreira, Willian-
Autor(es): dc.creatorPavan, Jacqueline C.-
Autor(es): dc.creatorCrestani, Carlos C.-
Autor(es): dc.creatorMarin, Marcelo T.-
Data de aceite: dc.date.accessioned2025-08-21T21:32:18Z-
Data de disponibilização: dc.date.available2025-08-21T21:32:18Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-02-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fphys.2021.781447-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223554-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223554-
Descrição: dc.descriptionProlonged and heightened responses to stress are known factors that influence the development of mood disorders and cardiovascular diseases. Moreover, the coping strategies related to the experience of adverse events, i.e., resilience or the susceptibility to stress, are determinants for the individual risk of developing such diseases. Susceptible rats to the social defeat stress (SDS), identified by the social interaction test (SIT), show behavioral and cardiovascular alterations after SDS exposure that are not found in resilient rats. However, it is not elucidated yet how the cardiovascular system of susceptible and resilient phenotypes responds to a new stressor after SDS exposure. Thus, using the SDS exposure followed by the SIT, we evaluated heart rate, blood pressure (BP), tail skin temperature, and circulating corticosterone responses to an acute session of restraint stress in susceptible and resilient rats to SDS. Susceptible rats showed resting tachycardia and exaggerated BP response to restraint stress, while resilient rats did not present such alterations. In contrast, both phenotypes showed increased plasma corticosterone and a drop in tail skin temperature to restraint stress, which was similar to that observed in control animals. Our results revealed an increased cardiovascular reactivity in response to a new stressful stimulus in susceptible rats, which might be related to a greater risk for the development of cardiovascular diseases.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionLaboratory of Pharmacology School of Pharmaceutical Sciences of Araraquara São Paulo State University-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences (PIPGCF) UFSCar/UNESP-
Descrição: dc.descriptionLaboratory of Pharmacology School of Pharmaceutical Sciences of Araraquara São Paulo State University-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences (PIPGCF) UFSCar/UNESP-
Descrição: dc.descriptionFAPESP: 2015/25308-3-
Descrição: dc.descriptionCAPES: Finance Code 001-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectblood pressure-
Palavras-chave: dc.subjectdepression-
Palavras-chave: dc.subjectheart rate-
Palavras-chave: dc.subjectresilience-
Palavras-chave: dc.subjectrestraint stress-
Palavras-chave: dc.subjectsocial defeat stress-
Palavras-chave: dc.subjectsusceptibility-
Título: dc.titleCardiovascular Reactivity to a Novel Stressor: Differences on Susceptible and Resilient Rats to Social Defeat Stress-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.