In vitro and in vivo cytotoxicity assessment of glyphosate and imazethapyr-based herbicides and their association

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Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorState University of Rio de Janeiro-
Autor(es): dc.contributorFluminense Federal University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFederal University of Paraná-
Autor(es): dc.creatorCosta, Gessyca-
Autor(es): dc.creatorFernandes, Andréia-
Autor(es): dc.creatorSantos, Thaís-
Autor(es): dc.creatorBrito, Lara-
Autor(es): dc.creatorRodrigues, Laís-
Autor(es): dc.creatorValadares, Marize-
Autor(es): dc.creatorFelzenszwalb, Israel-
Autor(es): dc.creatorFerraz, Elisa-
Autor(es): dc.creatorMorais Leme, Daniela-
Autor(es): dc.creatorOliveira, Gisele-
Data de aceite: dc.date.accessioned2025-08-21T19:31:21Z-
Data de disponibilização: dc.date.available2025-08-21T19:31:21Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1080/15287394.2022.2036281-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223540-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223540-
Descrição: dc.descriptionResistance to glyphosate herbicide has initiated usage of combined application of herbicides as a weed control measure. Imazethapyr-based herbicides associated with glyphosate herbicide seem to be an alternative to suppress weed resistance. The aim of this study was to examine the adverse effects of Glyphosate Atanor 48® (ATN) and Imazethapyr Plus Nortox® (IMZT) formulations in both single forms and mixtures using HepG2 cells and zebrafish early-life stages models. Data demonstrated cytotoxicity due to exposure to ATN, IMZT for both models, as follows: (1) ATN (0.5 mg/L), IMZT (5 mg/L), and M3 (0.05 mg/L ATN + 5 mg/L IMZT) increased cytotoxicity by disturbing the mitochondrial activity of HepG2 cells 24 hr after exposure; (2) ATN and IMZT (5 mg/L), and M3 (0.05 mg/L ATN + 5 mg/L IMZT) also decreased the integrity of the membrane of HepG2 cells after 24 hr incubation; (3) only ATN and IMZT (5 mg/L) in their single forms diminished the mitochondrial potential of zebrafish; (4) ATN (single form) at 0.5 mg/L induced apoptosis in zebrafish larvae. In conclusion, these herbicides in their single forms appeared to produce greater cytotoxicity to HepG2 cells and zebrafish compared to the herbicide mixtures.-
Descrição: dc.descriptionEnvironmental Toxicology Research Laboratory Faculty of Pharmacy Federal University of Goiás-
Descrição: dc.descriptionDepartment of Biophysics and Biometry Institute of Biology Roberto Alcantara Gomes State University of Rio de Janeiro-
Descrição: dc.descriptionLaboratory of Teaching and Research in Toxicology in Vitro Faculty of Pharmacy Federal University of Goiás-
Descrição: dc.descriptionDepartment of Pharmacy and Pharmaceutical Administration Pharmacy College Fluminense Federal University-
Descrição: dc.descriptionInstitute of Chemistry National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives UNESP-
Descrição: dc.descriptionDepartament of Genetics Federal University of Paraná-
Descrição: dc.descriptionInstitute of Chemistry National Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives UNESP-
Idioma: dc.languageen-
Relação: dc.relationJournal of Toxicology and Environmental Health - Part A: Current Issues-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectcytotoxicity-
Palavras-chave: dc.subjectFormulations-
Palavras-chave: dc.subjectHepG2-
Palavras-chave: dc.subjectmixtures-
Palavras-chave: dc.subjectzebrafish-
Título: dc.titleIn vitro and in vivo cytotoxicity assessment of glyphosate and imazethapyr-based herbicides and their association-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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