Anti-Inflammatory Efficacy of Curcumin as an Adjunct to Non-Surgical Periodontal Treatment: A Systematic Review and Meta-Analysis

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorSichuan University-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Amsterdam and Vrije Universiteit Amsterdam-
Autor(es): dc.creatorZhang, Yang-
Autor(es): dc.creatorHuang, Lei-
Autor(es): dc.creatorZhang, Jinmei-
Autor(es): dc.creatorDe Souza Rastelli, Alessandra Nara-
Autor(es): dc.creatorYang, Jingmei-
Autor(es): dc.creatorDeng, Dongmei-
Data de aceite: dc.date.accessioned2025-08-21T20:26:43Z-
Data de disponibilização: dc.date.available2025-08-21T20:26:43Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-01-23-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fphar.2022.808460-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223422-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223422-
Descrição: dc.descriptionObjective: Curcumin has been used as an adjunct to non-surgical periodontal treatment. However, the efficacy of curcumin in the periodontal therapy remained controversial. This study aimed to evaluate the anti-inflammatory efficacy of curcumin as an adjunct to non-surgical periodontal treatment (NPT) by systematic review. Methods: Databases including Embase, PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), and ClinicalTrials.gov were searched to identify relevant RCTs on the use of curcumin as an adjunct to NPT for the treatment of periodontal disease from inception to July 21, 2021. Two reviewers independently screened literature, extracted data and assessed the risk of bias of the included studies. Meta-analysis was then performed using Review Manager 5.3 software. Results: A total of 18 RCTs involving 846 patients/sites were included in this meta-analysis. The results of the meta-analysis revealed that as compared to NPT alone, curcumin as an adjunct to NPT resulted in significant reduction in gingival index (GI) at the 1-week (mean differences (MD) = −0.15, 95% confidence intervals (CI) −0.26 to −0.05, p = 0.005), 2-week (MD = −0.51, 95%CI −0.74 to −0.28, p < 0.0001), 3-week (MD = −0.34, 95%CI −0.66 to −0.02, p = 0.03), 4-week (MD = −0.25, 95%CI −0.48 to −0.02, p = 0.04) or 6-week (MD = −0.33, 95%CI −0.58 to −0.08, p = 0.01) follow-ups. Similar significant reductions were also observed for sulcus bleeding index (SBI) at 1, 2, 4, and 12 weeks. However, there were no statistically significant differences in reducing bleeding on probing (BOP) between curcumin as an adjunct and NPT alone at 4, 12, and 24 weeks. Conclusion: Based on the current evidence, curcumin demonstrates anti-inflammatory efficacies in terms of reducing GI and SBI compared with NPT alone. Moreover, curcumin is a natural herbal medicine with few side effects, and it is a good candidate as an adjunct treatment for periodontal disease.-
Descrição: dc.descriptionDepartment of Periodical Press and National Clinical Research Center for Geriatrics West China Hospital Sichuan University-
Descrição: dc.descriptionChinese Evidence-Based Medicine Center West China Hospital Sichuan University-
Descrição: dc.descriptionSchool of Public Health and West China Fourth Hospital Sichuan University-
Descrição: dc.descriptionState Key Laboratory of Oral Disease and National Clinical Research Center for Oral Disease Department of Periodontics West China Hospital of Stomatology Sichuan University-
Descrição: dc.descriptionDepartment of Restorative Dentistry School of Dentistry São Paulo State University-UNESP-
Descrição: dc.descriptionDepartment of Preventive Dentistry Academic Centre for Dentistry Amsterdam University of Amsterdam and Vrije Universiteit Amsterdam-
Descrição: dc.descriptionDepartment of Restorative Dentistry School of Dentistry São Paulo State University-UNESP-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Pharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanti-inflammatory-
Palavras-chave: dc.subjectcurcumin-
Palavras-chave: dc.subjectmeta-analysis-
Palavras-chave: dc.subjectnon-surgical periodontal treatment (NPT)-
Palavras-chave: dc.subjectperiodontal disease-
Título: dc.titleAnti-Inflammatory Efficacy of Curcumin as an Adjunct to Non-Surgical Periodontal Treatment: A Systematic Review and Meta-Analysis-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.