Structural and Ultrastructural Changes in the Tongue of mdx Mice

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorTomiate, André N.-
Autor(es): dc.creatorBarbosa, Gabriela K.-
Autor(es): dc.creatorRici, Rose E. G.-
Autor(es): dc.creatorDe Almeida, Sonia Regina Y.-
Autor(es): dc.creatorWatanabe, Ii-Sei-
Autor(es): dc.creatorCiena, Adriano P.-
Data de aceite: dc.date.accessioned2025-08-21T20:11:00Z-
Data de disponibilização: dc.date.available2025-08-21T20:11:00Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1017/S1431927622000022-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223402-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223402-
Descrição: dc.descriptionThe mdx mouse is an experimental model of Duchenne muscular dystrophy, a genetic disorder characterized by progressive muscular degeneration which affects the oral cavity musculature, and promotes difficulty in swallowing. This study aimed to describe morphological, structural, and ultrastructural changes in the tongue mucosa and musculature of mdx mice. Forty six-month-old mice were divided into two groups: Control C57bl/10 (n = 20) and mdx C57bl/10mdx (n = 20). The tongue was dissected and analyzed with light microscopy, scanning electron microscopy, and transmission electron microscopy techniques. Our results showed conical and triangular filiform, fungiform, foliate, and vallate papillae, and their connective tissue cores. The epithelium layers identified were corneum, granulosum, spinosum, and basale. The mdx group had a thicker epithelium. Lamina propria was composed of reddish and greenish collagen. In mdx, collagen was present in the musculature of the tongue's body and in the muscular tissue between mucous and serous glands of the caudal region. Musculature was also characterized by a shorter length of sarcoplasmic invaginations, myocytolysis in mitochondrial groupings, and inflammatory focus. In conclusion, the tongue of 6-month-old mdx mice had morphology, structure, and ultrastructure revealed, showing higher wear of filiform papillae indirect reflex from the muscular degeneration process.-
Descrição: dc.descriptionLaboratório de Morfologia e Atividade Física (LAMAF) Instituto de Biociências Universidade Estadual Paulista (UNESP) São Paulo-
Descrição: dc.descriptionDepartamento de Cirurgia Faculdade de Medicina Veterinária e Zootecnia Universidade de São Paulo-
Descrição: dc.descriptionDepartamento de Anatomia Instituto de Ciências Biomédicas-ICB Iii Universidade de São Paulo-
Descrição: dc.descriptionLaboratório de Morfologia e Atividade Física (LAMAF) Instituto de Biociências Universidade Estadual Paulista (UNESP) São Paulo-
Idioma: dc.languageen-
Relação: dc.relationMicroscopy and Microanalysis-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectanimal model-
Palavras-chave: dc.subjectconnective tissue cores-
Palavras-chave: dc.subjectDuchenne muscular dystrophy-
Palavras-chave: dc.subjectlingual papillae-
Palavras-chave: dc.subjectmuscular degeneration-
Palavras-chave: dc.subjectrodents-
Título: dc.titleStructural and Ultrastructural Changes in the Tongue of mdx Mice-
Tipo de arquivo: dc.typelivro digital-
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