Mapping Bone Marrow Cell Response from Senile Female Rats on Ca-P-Doped Titanium Coating

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Guarulhos (UnG)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversity of Illinois at Chicago-
Autor(es): dc.creatorFaverani, Leonardo P.-
Autor(es): dc.creatorSilva, William P. P.-
Autor(es): dc.creatorde Sousa, Cecília Alves-
Autor(es): dc.creatorFreitas, Gileade-
Autor(es): dc.creatorBassi, Ana Paula F.-
Autor(es): dc.creatorShibli, Jamil A.-
Autor(es): dc.creatorBarão, Valentim A. R.-
Autor(es): dc.creatorRosa, Adalberto L.-
Autor(es): dc.creatorSukotjo, Cortino-
Autor(es): dc.creatorAssunção, Wirley G.-
Data de aceite: dc.date.accessioned2025-08-21T19:45:58Z-
Data de disponibilização: dc.date.available2025-08-21T19:45:58Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ma15031094-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223355-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223355-
Descrição: dc.descriptionChemical and topographical surface modifications on dental implants aim to increase the bone surface contact area of the implant and improve osseointegration. This study analyzed the cellular response of undifferentiated mesenchymal stem cells (MSC), derived from senile rats’ femoral bone marrow, when cultured on a bioactive coating (by plasma electrolytic oxidation, PEO, with Ca2+ and P5+ ions), a sandblasting followed by acid-etching (SLA) surface, and a machined surface (MSU). A total of 102 Ti-6Al-4V discs were divided into three groups (n = 34). The surface chemistry was analyzed by energy dispersive spectroscopy (EDS). Cell viability assay, gene expression of osteoblastic markers, and mineralized matrix formation were investigated. The cell growth and viability results were higher for PEO vs. MSU surface (p = 0.001). An increase in cell proliferation from 3 to 7 days (p < 0.05) and from 7 to 10 days (p < 0.05) was noted for PEO and SLA surfaces. Gene expression for OSX, ALP, BSP, and OPN showed a statistical significance (p = 0.001) among groups. In addition, the PEO surface showed a higher mineralized matrix bone formation (p = 0.003). In conclusion, MSC from senile female rats cultured on SLA and PEO surfaces showed similar cellular responses and should be considered for future clinical investigations.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Division of Oral and Maxillofacial Surgery and Implantology School of Dentistry São Paulo State University—UNESP-
Descrição: dc.descriptionDental Prosthesis Department of Dental Materials and Prosthodontics School of Dentistry São Paulo State University—UNESP-
Descrição: dc.descriptionBone Res Lab School of Dentistry of Ribeirao Preto University of São Paulo (USP)-
Descrição: dc.descriptionDepartment of Periodontology and Oral Implantology Dental Research Division University of Guarulhos (UnG)-
Descrição: dc.descriptionDepartment of Prosthodontics and Periodontology Piracicaba Dental School University of Campinas (UNICAMP)-
Descrição: dc.descriptionDepartment of Restorative Dentistry College of Dentistry University of Illinois at Chicago-
Descrição: dc.descriptionDepartment of Diagnosis and Surgery Division of Oral and Maxillofacial Surgery and Implantology School of Dentistry São Paulo State University—UNESP-
Descrição: dc.descriptionDental Prosthesis Department of Dental Materials and Prosthodontics School of Dentistry São Paulo State University—UNESP-
Descrição: dc.descriptionFAPESP: 2016/20297-6-
Idioma: dc.languageen-
Relação: dc.relationMaterials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDental implants-
Palavras-chave: dc.subjectOxidation-
Palavras-chave: dc.subjectStromal mesenchymal cells-
Palavras-chave: dc.subjectTitanium surfaces-
Título: dc.titleMapping Bone Marrow Cell Response from Senile Female Rats on Ca-P-Doped Titanium Coating-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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