Beta-hydroxy-beta-methylbutyrate associated with low-intensity exercise training improves skeletal muscle regeneration through the IGF-Akt pathway

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Metodista de Piracicaba-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Paulista-Swift-
Autor(es): dc.creatorYamada, A. K.-
Autor(es): dc.creatorFerretti, R.-
Autor(es): dc.creatorMatsumura, C. Y.-
Autor(es): dc.creatorAntunes, L.-
Autor(es): dc.creatorda Silva, C. A.-
Autor(es): dc.creatorPertille, A.-
Data de aceite: dc.date.accessioned2025-08-21T22:37:17Z-
Data de disponibilização: dc.date.available2025-08-21T22:37:17Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/1414-431X2021e11597-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223341-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223341-
Descrição: dc.descriptionThe effect of beta-hydroxy-beta-methylbutyrate (HMB) supplementation associated with exercise training at different intensities and frequencies on skeletal muscle regeneration of muscle-injured rats was investigated. Male Wistar rats were divided into sedentary and trained groups. The sedentary groups were subdivided into non-injured (SED-Ct), non-injured supplemented with HMB (SED-Ct-HMB), injured (SED), and injured with HMB (SED-HMB), and the trained groups were injured, supplemented with HMB, and then divided into training three times a week without load (HT3) or with load (HT3L) and training five times a week without load (HT5) and with load (HT5L). The rats received a daily dose of HMB associated with 60 min of swimming with or without 5% body mass load for 14 days. On the 15th day, cryoinjury was performed in the right tibialis anterior muscle (TA), and 48 h later, supplementation and training continued for 15 days. After the last session, the TA was dissected and a cross-sectional area (CSA) of muscle fibers was used to determine the percentage of CSA fibers and connective tissue (%CT), as well as the total and phosphorylated protein contents. SED-HMB showed increased CSA and decreased %CT and TGF-b when compared to SED. HT3 showed increased CSA and reduced %CT accompanied by increased IGF-1/Akt, myogenin, and MuRF1, and decreased TGF-b. The CSA of HT5L also increased, but at the cost of a higher %CT compared to the other groups. Our results demonstrated that HMB associated with training without load and with lower frequency per week may be a valuable strategy for skeletal muscle regeneration.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionPrograma de Pós-Graduac¸ão em Ciências do Movimento Humano Laboratório de Plasticidade Neuromuscular Universidade Metodista de Piracicaba, SP-
Descrição: dc.descriptionDepartamento de Biologia Estrutural e Funcional Instituto de Biociências de Botucatu Universidade Estadual Paulista, SP-
Descrição: dc.descriptionInstituto de Ciências da Saúde Faculdade de Ciências da Saúde Universidade Paulista-Swift, SP-
Descrição: dc.descriptionDepartamento de Biologia Estrutural e Funcional Instituto de Biociências de Botucatu Universidade Estadual Paulista, SP-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionCNPq: 423505/2016-5-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Medical and Biological Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectExercise-
Palavras-chave: dc.subjectInjury-
Palavras-chave: dc.subjectMuscle-
Palavras-chave: dc.subjectRegeneration-
Palavras-chave: dc.subjectSignaling pathways-
Palavras-chave: dc.subjectSupplementation-
Título: dc.titleBeta-hydroxy-beta-methylbutyrate associated with low-intensity exercise training improves skeletal muscle regeneration through the IGF-Akt pathway-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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