Bacterial nanocellulose containing diethylditiocarbamate bio-curatives: physicochemical characterization and drug delivery evaluation

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorIGM- FIOCRUZ-BA-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniara-
Autor(es): dc.contributorINCT-DT- Instituto de Investigação Em Doenças Tropicais-
Autor(es): dc.creatorBorba, Pedro B.-
Autor(es): dc.creatorMeneguin, Andréia Bagliotti-
Autor(es): dc.creatorSilva, Jhonatan Miguel-
Autor(es): dc.creatorda Silva Barud, Hernane-
Autor(es): dc.creatorde Oliveira, Camila I.-
Data de aceite: dc.date.accessioned2025-08-21T22:00:31Z-
Data de disponibilização: dc.date.available2025-08-21T22:00:31Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-01-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10570-021-04360-1-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223329-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223329-
Descrição: dc.descriptionBacterial nanocellulose (BNC) is a natural biopolymer produced by different strains of acetic acid bacteria. Biocompatibility, lack of immunogenicity, mechanical strength and crystallinity make BNC a highly applicable product for drug delivery and wound dressing. Previously, we demonstrated that diethylditiocarbamate (DETC), a Superoxide Dismutase 1 inhibitor, incorporated into BNC bio-curatives was effective for treating Cutaneous leishmaniasis (CL) lesions, a parasitic disease caused by Leishmania. We herein investigated the interactions between DETC and BNC. For this purpose, DETC was incorporated into BNC and thermal analysis, x-ray diffraction and Scanning electron microscopy were performed. Furthermore, in vitro DETC release and stability tests as well as degradation studies were also performed. Our results show that DETC is well incorporated into BNC, however it is short lived as suggested by degradation experiments. Future use of BNC DETC-based bio-curatives for the treatment of CL shall require further development in order to increase stability of DETC in the bio-curative.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionIGM- FIOCRUZ-BA, BA-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University UNESP, SP-
Descrição: dc.descriptionUniara, SP-
Descrição: dc.descriptionINCT-DT- Instituto de Investigação Em Doenças Tropicais, BA-
Descrição: dc.descriptionSchool of Pharmaceutical Sciences São Paulo State University UNESP, SP-
Descrição: dc.descriptionCAPES: 001-
Formato: dc.format1557-1565-
Idioma: dc.languageen-
Relação: dc.relationCellulose-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDegradation-
Palavras-chave: dc.subjectDiethylditiocarbamate-
Palavras-chave: dc.subjectLeishmaniasis-
Palavras-chave: dc.subjectTopical delivery-
Título: dc.titleBacterial nanocellulose containing diethylditiocarbamate bio-curatives: physicochemical characterization and drug delivery evaluation-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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