Potentially Probiotic Limosilactobacillus fermentum Fruit-Derived Strains Alleviate Cardiometabolic Disorders and Gut Microbiota Impairment in Male Rats Fed a High-Fat Diet

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Autor(es): dc.contributorFederal University of Paraiba-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Illinois at Chicago-
Autor(es): dc.contributorFederal University of Paraíba-
Autor(es): dc.creatorde Araújo Henriques Ferreira, Georgianna-
Autor(es): dc.creatorMagnani, Marciane-
Autor(es): dc.creatorCabral, Lucélia-
Autor(es): dc.creatorBrandão, Larissa Ramalho-
Autor(es): dc.creatorNoronha, Melline Fontes-
Autor(es): dc.creatorde Campos Cruz, Josiane-
Autor(es): dc.creatorde Souza, Evandro Leite-
Autor(es): dc.creatorde Brito Alves, José Luiz-
Data de aceite: dc.date.accessioned2025-08-21T15:18:34Z-
Data de disponibilização: dc.date.available2025-08-21T15:18:34Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s12602-021-09889-y-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223328-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223328-
Descrição: dc.descriptionHigh-fat diet (HFD) consumption is a risk factor for dyslipidemias, insulin resistance, and arterial hypertension linked with gut dysbiosis. Probiotic administration has been suggested as a safe therapeutic strategy for gut microbiota modulation and treatment and/or prevention of cardiometabolic disorders. Here, we assessed the effects of a potentially probiotic formulation containing strains of the Limosilactobacillus (L.) fermentum 139, 263, and 296 on the cardiometabolic disorders and gut microbiota derangements provoked by the HFD consumption. Male Wistar rats were allocated into control diet (CTL, n = 6), HFD (n = 6), and HFD receiving L. fermentum formulation (HFD-LF, n = 6) groups for 4 weeks. L. fermentum formulation (109 colony-forming unit (CFU)/ml of each strain) was daily administered by oral gavage. After 4-week follow-up, biochemical measurements, blood pressure (BP), heart rate (HR), sympathetic tone, and gut microbiota composition were evaluated. HFD consumption for 4 weeks increased lipid profile, insulin resistance, sympathetic tone, and blood pressure and impaired gut microbiota composition in male rats. Administration of L. fermentum formulation improved the gut microbiota composition, lipid profile, insulin resistance, autonomic dysfunction, and BP in rats fed with a HFD. Administration of a potentially fruit-derived probiotic formulation of L. fermentum strains improved gut microbiota composition and alleviated hyperlipidemia, insulin resistance, and sympathetic hyperactivity and increased BP in rats fed a HFD. Our findings may encourage the development of randomized controlled trials to assess the effects of L. fermentum treatment in subjects with cardiometabolic disorders.-
Descrição: dc.descriptionDepartment of Nutrition Health Sciences Center Federal University of Paraiba Campus I – Jd. Cidade Universitária-
Descrição: dc.descriptionDepartment of Food Engineering Technology Center Federal University of Paraiba-
Descrição: dc.descriptionInstitute of Biosciences Department of General and Applied Biology São Paulo State University (UNESP)-
Descrição: dc.descriptionResearch Resource Center Research Informatics Core University of Illinois at Chicago-
Descrição: dc.descriptionDepartment of Biotechnology Biotechnology Center Federal University of Paraíba-
Descrição: dc.descriptionInstitute of Biosciences Department of General and Applied Biology São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationProbiotics and Antimicrobial Proteins-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBlood pressure-
Palavras-chave: dc.subjectDyslipidemia-
Palavras-chave: dc.subjectHigh-fat diet-
Palavras-chave: dc.subjectLimosilactobacillus fermentum-
Palavras-chave: dc.subjectProbiotic-
Título: dc.titlePotentially Probiotic Limosilactobacillus fermentum Fruit-Derived Strains Alleviate Cardiometabolic Disorders and Gut Microbiota Impairment in Male Rats Fed a High-Fat Diet-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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