Screening of coformers for quercetin cocrystals through mechanochemical methods

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorDe Souza, Fayene Zeferino Ribeiro-
Autor(es): dc.creatorDe Almeida, Amanda Cosmo-
Autor(es): dc.creatorFerreira, Patrícia Osorio-
Autor(es): dc.creatorFernandes, Richard Perosa-
Autor(es): dc.creatorCaires, Flávio Junior-
Data de aceite: dc.date.accessioned2025-08-21T17:38:12Z-
Data de disponibilização: dc.date.available2025-08-21T17:38:12Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.26850/1678-4618eqj.v47.1.2022.p64-75-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223320-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223320-
Descrição: dc.descriptionQuercetin (QUE) is a nutraceutical compound that exhibits pharmacological properties such as antioxidant, cardioprotective, anti-ulcer, and anti-inflammatory effects. Although QUE is well-known for its benefits, its efficacy is limited due to low solubility. Thus, cocrystallization acts as an interesting approach to improve the solubility - among other properties - of this compound. In this work, cocrystallization screening was applied through neat grinding (NG) and liquid-assisted grinding (LAG), in which QUE and four cocrystal formers (benzamide, picolinamide, isonicotinamide, and pyrazinoic acid) were tested. The precursors and QUE-coformer systems were characterized using thermoanalytical techniques (TG-DTA), X-ray powder diffraction (XRPD), and Fourier transform infrared (FTIR) spectroscopy. The results showed the formation of QUE cocrystals with picolinamide and isonicotinamide coformers in a 1:1 stoichiometric ratio. Furthermore, although coformers are isomers, spectroscopic and thermal data suggest that the supramolecular synthons involved in cocrystallization are different.-
Descrição: dc.descriptionSão Paulo State University School of Science-
Descrição: dc.descriptionSão Paulo State University Institute of Chemistry-
Descrição: dc.descriptionSão Paulo State University School of Science-
Descrição: dc.descriptionSão Paulo State University Institute of Chemistry-
Formato: dc.format64-75-
Idioma: dc.languageen-
Relação: dc.relationEcletica Quimica-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCocrystallization-
Palavras-chave: dc.subjectFlavonoid-
Palavras-chave: dc.subjectMechanochemistry-
Palavras-chave: dc.subjectNutraceutical-
Palavras-chave: dc.subjectThermal analysis-
Título: dc.titleScreening of coformers for quercetin cocrystals through mechanochemical methods-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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