The Serum Concentration of Vancomycin as a Diagnostic Predictor of Nephrotoxic Acute Kidney Injury in Critically Ill Patients

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorBotucatu School of Medicine-
Autor(es): dc.creatorZamoner, Welder-
Autor(es): dc.creatorEid, Karina Zanchetta Cardoso-
Autor(es): dc.creatorde Almeida, Lais Maria Bellaver-
Autor(es): dc.creatorPierri, Isabella Gonçalves-
Autor(es): dc.creatorDos Santos, Adriano-
Autor(es): dc.creatorBalbi, André Luis-
Autor(es): dc.creatorPonce, Daniela-
Data de aceite: dc.date.accessioned2025-08-21T19:53:26Z-
Data de disponibilização: dc.date.available2025-08-21T19:53:26Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/antibiotics11010112-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223300-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223300-
Descrição: dc.descriptionThe impact of serum concentrations of vancomycin is a controversial topic. Results: 182 critically ill patients were evaluated using vancomycin and 63 patients were included in the study. AKI occurred in 44.4% of patients on the sixth day of vancomycin use. Vancomycin higher than 17.53 mg/L between the second and the fourth days of use was a predictor of AKI, preceding AKI diagnosis for at least two days, with an area under the curve of 0.806 (IC 95% 0.624–0.987, p = 0.011). Altogether, 46.03% of patients died, and in the Cox analysis, the associated factors were age, estimated GFR, CPR, and vancomycin between the second and the fourth days. Discussion: The current 2020 guidelines recommend using Bayesian-derived AUC monitoring rather than trough concentrations. However, due to the higher number of laboratory analyses and the need for an application to calculate the AUC, many centers still use therapeutic trough levels between 15 and 20 mg/L. Conclusion: The results of this study suggest that a narrower range of serum concentration of vancomycin was a predictor of AKI in critically ill septic patients, preceding the diagnosis of AKI by at least 48 h, and it can be a useful monitoring tool when AUC cannot be used.-
Descrição: dc.descriptionBotucatu School of Medicine University São Paulo State—UNESP, SP-
Descrição: dc.descriptionClinics Hospital Pharmacy Botucatu School of Medicine, SP-
Descrição: dc.descriptionBotucatu School of Medicine University São Paulo State—UNESP, SP-
Idioma: dc.languageen-
Relação: dc.relationAntibiotics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcute kidney injury-
Palavras-chave: dc.subjectNephrotoxicity-
Palavras-chave: dc.subjectSepsis-
Palavras-chave: dc.subjectVancomycin-
Título: dc.titleThe Serum Concentration of Vancomycin as a Diagnostic Predictor of Nephrotoxic Acute Kidney Injury in Critically Ill Patients-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.