Oxidative stress biomarkers in treatment-responsive and treatment-resistant schizophrenia patients

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorFaculdade de Medicina de São José do Rio Preto (FAMERP)-
Autor(es): dc.contributorFAMERP-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorSC-
Autor(es): dc.creatorBuosi, Patrick-
Autor(es): dc.creatorBorghi, Fábio Aparecido-
Autor(es): dc.creatorLopes, Angélica Marta-
Autor(es): dc.creatorFacincani, Isabela da Silva-
Autor(es): dc.creatorFernandes-Ferreira, Rafael-
Autor(es): dc.creatorOliveira-Brancati, Camila Ive Ferreira-
Autor(es): dc.creatordo Carmo, Tayanne Silva-
Autor(es): dc.creatorSouza, Dorotéia Rossi Silva-
Autor(es): dc.creatorda Silva, Danilo Grünig Humberto-
Autor(es): dc.creatorde Almeida, Eduardo Grünig Humberto-
Autor(es): dc.creatorde Araújo Filho, Gerardo Maria-
Data de aceite: dc.date.accessioned2025-08-21T21:18:32Z-
Data de disponibilização: dc.date.available2025-08-21T21:18:32Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.47626/2237-6089-2020-0078-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223298-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223298-
Descrição: dc.descriptionINTRODUCTION: Schizophrenia is a complex psychiatric disorder that affects approximately twenty million people worldwide. Various factors have been associated with the physiopathology of this disease such as oxidative stress, which is an imbalance between pro-oxidant and antioxidant molecules. OBJECTIVE: This study evaluated the association between biomarkers of oxidative stress and response to pharmacological treatment among patients with schizophrenia in the context of their clinical information, demographic data, and lifestyle. METHODS: A total of 89 subjects were included, 26 of whom were treatment-responsive schizophrenia patients (Group 1), 27 treatment-resistant schizophrenia patients (Group 2), and 36 healthy controls (Group 3). All of the subjects completed a questionnaire to provide clinical and demographic data, and all provided peripheral blood samples. The oxidative stress markers analyzed using spectrophotometry were catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx), total glutathione (GSH-t), malondialdehyde (MDA), and Trolox-equivalent antioxidant capacity (TEAC; p < 0.05). RESULTS: When all schizophrenia patients (G1 + G2) were compared to the control group, SOD levels were found to be lower among schizophrenia patients (p < 0.0001), while MDA and CAT levels were higher (p < 0.0001 and p = 0.0191, respectively). GPx, GSH-t, and TEAC levels were similar in all three groups (p > 0.05). CONCLUSION: Lower SOD levels and higher MDA and CAT levels indicate oxidative damage in schizophrenia patients, regardless of their response to pharmacological treatment. Smoking is associated with oxidative stress, in addition, a family history of the disease was also found to be correlated with cases of schizophrenia, which reflects the relevance of genetics in disease development.-
Descrição: dc.descriptionHospital de Base Faculdade de Medicina de São José do Rio Preto (FAMERP)-
Descrição: dc.descriptionFAMERP-
Descrição: dc.descriptionUniversidade Estadual de Campinas (UNICAMP), Campinas, SP, Brazil. Universidade Paulista (UNIP), São José do Rio Preto, SP, Brazil-
Descrição: dc.descriptionUniversidade Estadual Paulista São José do Rio Preto Campus (UNESP), Instituto de Biociencias Letras e Ciencias Exatas Campus de São José do Rio Preto (IBILCE)-
Descrição: dc.descriptionDepartamento de Ciências Naturais Universidade Regional de Blumenau (FURB) SC-
Descrição: dc.descriptionUniversidade Estadual Paulista São José do Rio Preto Campus (UNESP), Instituto de Biociencias Letras e Ciencias Exatas Campus de São José do Rio Preto (IBILCE)-
Formato: dc.format278-285-
Idioma: dc.languageen-
Relação: dc.relationTrends in psychiatry and psychotherapy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantioxidants-
Palavras-chave: dc.subjectfree radicals-
Palavras-chave: dc.subjectoxidative stress-
Palavras-chave: dc.subjectPsychotic disorders-
Palavras-chave: dc.subjecttreatment resistance-
Título: dc.titleOxidative stress biomarkers in treatment-responsive and treatment-resistant schizophrenia patients-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.