Thrombotic microangiopathy in children

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorMayo Clinic-
Autor(es): dc.creatorPalma, Lilian Monteiro P.-
Autor(es): dc.creatorVaisbich-Guimarães, Maria Helena-
Autor(es): dc.creatorSridharan, Meera-
Autor(es): dc.creatorTran, Cheryl L.-
Autor(es): dc.creatorSethi, Sanjeev-
Data de aceite: dc.date.accessioned2025-08-21T17:30:25Z-
Data de disponibilização: dc.date.available2025-08-21T17:30:25Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00467-021-05370-8-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223288-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223288-
Descrição: dc.descriptionThe syndrome of thrombotic microangiopathy (TMA) is a clinical-pathological entity characterized by microangiopathic hemolytic anemia, thrombocytopenia, and end organ involvement. It comprises a spectrum of underlying etiologies that may differ in children and adults. In children, apart from ruling out shigatoxin-associated hemolytic uremic syndrome (HUS) and other infection-associated TMA like Streptococcus pneumoniae-HUS, rare inherited causes including complement-associated HUS, cobalamin defects, and mutations in diacylglycerol kinase epsilon gene must be investigated. TMA should also be considered in the setting of solid organ or hematopoietic stem cell transplantation. In this review, acquired and inherited causes of TMA are described with a focus on particularities of the main causes of TMA in children. A pragmatic approach that may help the clinician tailor evaluation and management is provided. The described approach will allow for early initiation of treatment while waiting for the definitive diagnosis of the underlying TMA.-
Descrição: dc.descriptionDepartment of Pediatrics Pediatric Nephrology State University of Campinas (UNICAMP) Rua Tessalia Vieira de Camargo, 126, Cidade Universitaria, SP-
Descrição: dc.descriptionPediatric Nephrology State University of São Paulo (USP)-
Descrição: dc.descriptionHematology Department of Internal Medicine Mayo Clinic-
Descrição: dc.descriptionPediatric Nephrology Department of Pediatrics Mayo Clinic-
Descrição: dc.descriptionDepartment of Laboratory Medicine and Pathology Mayo Clinic-
Idioma: dc.languageen-
Relação: dc.relationPediatric Nephrology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectComplement-
Palavras-chave: dc.subjectDGKe-
Palavras-chave: dc.subjectHemolytic uremic syndrome-
Palavras-chave: dc.subjectHypertension-
Palavras-chave: dc.subjectInfection-
Palavras-chave: dc.subjectThrombotic microangiopathy-
Palavras-chave: dc.subjectTransplant-
Título: dc.titleThrombotic microangiopathy in children-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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