Novel cinnamon-laden nanofibers as a potential antifungal coating for poly(methyl methacrylate) denture base materials

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Autor(es): dc.contributorUniversity of Michigan School of Dentistry-
Autor(es): dc.contributorFederal University of Pelotas-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Sergipe (UFS)-
Autor(es): dc.creatorRibeiro, Juliana Silva-
Autor(es): dc.creatorBordini, Ester Alves Ferreira-
Autor(es): dc.creatorPereira, Gabriel Kalil Rocha-
Autor(es): dc.creatorPolasani, Rohitha Rao-
Autor(es): dc.creatorSquarize, Cristiane Helena-
Autor(es): dc.creatorKantorski, Karla Zanini-
Autor(es): dc.creatorValandro, Luiz Felipe-
Autor(es): dc.creatorBottino, Marco Cícero-
Data de aceite: dc.date.accessioned2025-08-21T20:36:11Z-
Data de disponibilização: dc.date.available2025-08-21T20:36:11Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00784-021-04341-5-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223282-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223282-
Descrição: dc.descriptionObjectives: To modify the surface of denture base material by coating it with cinnamon-laden nanofibers to reduce Candida albicans (C. albicans) adhesion and/or proliferation. Materials and methods: Heat-cured poly(methyl methacrylate) (PMMA) specimens were processed and coated, or not, with cinnamon-laden polymeric nanofibers (20 or 40 wt.% of cinnamon relative to the total polymer weight). Scanning electron microscopy (SEM) and Fourier-transform infrared spectroscopy (FTIR) analyses of the nanofibers were performed. Antifungal activity was assessed through agar diffusion and colony-forming unit (CFU/mL) assays. Representative SEM morphological analysis was carried out to observe the presence/absence of C. albicans on the fibers. Alamar blue assay was used to determine cell toxicity. Analysis of variance and the Tukey’s test were used to analyze the data (α = 0.05). Results: SEM imaging revealed nanofibers with adequate (i.e., bead-free) morphological characteristics and uniform microstructure. FTIR confirmed cinnamon incorporation. The cinnamon-laden nanofibers led to growth inhibition of C. albicans. Viable fungal counts support a significant reduction on CFU/mL also directly related to cinnamon concentration (40 wt.%: mean log 6.17 CFU/mL < 20 wt.%: mean log 7.12 CFU/mL), which agrees with the SEM images. Cinnamon-laden nanofibers at 40 wt.% led to increased cell death. Conclusions: The deposition of 20 wt.% cinnamon-laden nanofibers onto PMMA surfaces led to a significant reduction of the adhesive and/or proliferative ability of C. albicans, while maintaining epithelial cells’ viability. Clinical relevance: The high recurrence rates of denture stomatitis are associated with patient non-adherence to treatments and contaminated prostheses use. Here, we provide the non-patients’ cooperation sensible method, which possesses antifungal action, hence improving treatment effectiveness.-
Descrição: dc.descriptionDepartment of Cariology Restorative Sciences and Endodontics University of Michigan School of Dentistry, 1011 N. University (Room 5223)-
Descrição: dc.descriptionDepartment of Restorative Dentistry School of Dentistry Federal University of Pelotas, RS-
Descrição: dc.descriptionDepartment of Physiology and Pathology University Estadual Paulista – UNESP, SP-
Descrição: dc.descriptionPost-Graduate Program in Oral Science Faculty of Dentistry Federal University of Santa Maria (UFSM), Rio Grande Do Sul State-
Descrição: dc.descriptionDepartment of Periodontics and Oral Medicine University of Michigan School of Dentistry-
Descrição: dc.descriptionDepartment of Physiology and Pathology University Estadual Paulista – UNESP, SP-
Idioma: dc.languageen-
Relação: dc.relationClinical Oral Investigations-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCandida albicans-
Palavras-chave: dc.subjectCinnamomum verum-
Palavras-chave: dc.subjectDenture stomatitis-
Palavras-chave: dc.subjectElectrospinning-
Palavras-chave: dc.subjectNanofibers-
Título: dc.titleNovel cinnamon-laden nanofibers as a potential antifungal coating for poly(methyl methacrylate) denture base materials-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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