Engineering of Injectable Antibiotic-Laden Fibrous Microparticles Gelatin Methacryloyl Hydrogel for Endodontic Infection Ablation

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Autor(es): dc.contributorUniversity of Michigan-
Autor(es): dc.contributorFederal University of Pelotas-
Autor(es): dc.contributorFederal University of Rio Grande do Sul-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Michigan School of Dentistry-
Autor(es): dc.creatorRibeiro, Juliana S.-
Autor(es): dc.creatorMünchow, Eliseu A.-
Autor(es): dc.creatorBordini, Ester A. F.-
Autor(es): dc.creatorRodrigues, Nathalie S.-
Autor(es): dc.creatorDubey, Nileshkumar-
Autor(es): dc.creatorSasaki, Hajime-
Autor(es): dc.creatorFenno, John C.-
Autor(es): dc.creatorSchwendeman, Steven-
Autor(es): dc.creatorBottino, Marco C.-
Data de aceite: dc.date.accessioned2025-08-21T16:01:38Z-
Data de disponibilização: dc.date.available2025-08-21T16:01:38Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms23020971-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223253-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223253-
Descrição: dc.descriptionThis study aimed at engineering cytocompatible and injectable antibiotic-laden fibrous microparticles gelatin methacryloyl (GelMA) hydrogels for endodontic infection ablation. Clindamycin (CLIN) or metronidazole (MET) was added to a polymer solution and electrospun into fibrous mats, which were processed via cryomilling to obtain CLIN-or MET-laden fibrous microparticles. Then, GelMA was modified with CLIN-or MET-laden microparticles or by using equal amounts of each set of fibrous microparticles. Morphological characterization of electrospun fibers and cryomilled particles was performed via scanning electron microscopy (SEM). The experimental hydrogels were further examined for swelling, degradation, and toxicity to dental stem cells, as well as antimicrobial action against endodontic pathogens (agar diffusion) and biofilm inhibition, evaluated both quantitatively (CFU/mL) and qualitatively via confocal laser scanning microscopy (CLSM) and SEM. Data were analyzed using ANOVA and Tukey’s test (α = 0.05). The modification of GelMA with antibiotic-laden fibrous microparticles increased the hydrogel swelling ratio and degradation rate. Cell viability was slightly reduced, although without any significant toxicity (cell viability > 50%). All hydrogels containing antibiotic-laden fibrous microparticles displayed antibiofilm effects, with the dentin substrate showing nearly complete elimination of viable bacteria. Altogether, our findings suggest that the engineered injectable antibiotic-laden fibrous microparticles hydrogels hold clinical prospects for endodontic infection ablation.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionNational Institute of Dental and Craniofacial Research-
Descrição: dc.descriptionNational Institutes of Health-
Descrição: dc.descriptionDepartment of Cariology Restorative Sciences and Endodontics School of Dentistry University of Michigan-
Descrição: dc.descriptionDepartment of Restorative Dentistry School of Dentistry Federal University of Pelotas, Rio Grande do Sul-
Descrição: dc.descriptionDepartment of Conservative Dentistry School of Dentistry Federal University of Rio Grande do Sul, Rio Grande do Sul-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University, São Paulo-
Descrição: dc.descriptionDepartment of Biologic and Materials Sciences & Prosthodontics University of Michigan School of Dentistry-
Descrição: dc.descriptionDepartment of Pharmaceutical Sciences and the Biointerfaces Institute University of Michigan-
Descrição: dc.descriptionDepartment of Biomedical Engineering College of Engineering University of Michigan-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University, São Paulo-
Descrição: dc.descriptionFAPESP: 2016/15674-5-
Descrição: dc.descriptionFAPESP: 2018/14257-7-
Descrição: dc.descriptionNational Institute of Dental and Craniofacial Research: K08DE023552-
Descrição: dc.descriptionNational Institutes of Health: K08DE023552-
Descrição: dc.descriptionNational Institute of Dental and Craniofacial Research: R01DE026578-
Descrição: dc.descriptionNational Institutes of Health: R01DE026578-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntibiotics-
Palavras-chave: dc.subjectBiodegradation-
Palavras-chave: dc.subjectCryomilling-
Palavras-chave: dc.subjectDentistry-
Palavras-chave: dc.subjectElectrospinning-
Palavras-chave: dc.subjectEndodontics-
Palavras-chave: dc.subjectFibrous particles-
Palavras-chave: dc.subjectRegeneration-
Título: dc.titleEngineering of Injectable Antibiotic-Laden Fibrous Microparticles Gelatin Methacryloyl Hydrogel for Endodontic Infection Ablation-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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