COVID-19 Outcome Relates With Circulating BDNF, According to Patient Adiposity and Age

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorPontificia Universidade Catolica do Parana-
Autor(es): dc.contributorCoimbra Health School-
Autor(es): dc.contributorLaboratory for Applied Health Research (LabinSaúde)-
Autor(es): dc.contributorJustus-Liebig-University Giessen-
Autor(es): dc.creatorMinuzzi, Luciele Guerra-
Autor(es): dc.creatorSeelaender, Marília-
Autor(es): dc.creatorSilva, Bruna Spolador De Alencar-
Autor(es): dc.creatorCunha, Eduardo del Bosco Brunetti-
Autor(es): dc.creatorDeus, Marina De Castro-
Autor(es): dc.creatorVasconcellos, Franciane Thais Falcão-
Autor(es): dc.creatorMarqueze, Luis Felipe Beltrão-
Autor(es): dc.creatorGadotti, Ana Carolina-
Autor(es): dc.creatorBaena, Cristina Pellegrino-
Autor(es): dc.creatorPereira, Telmo-
Autor(es): dc.creatorKrüger, Karsten-
Autor(es): dc.creatorAmaral, Andréa Novais Moreno-
Autor(es): dc.creatorPinho, Ricardo Aurino-
Autor(es): dc.creatorLira, Fábio Santos-
Data de aceite: dc.date.accessioned2025-08-21T15:41:54Z-
Data de disponibilização: dc.date.available2025-08-21T15:41:54Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-12-09-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fnut.2021.784429-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223106-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223106-
Descrição: dc.descriptionBackground and Aims: We evaluated adipose tissue-derived hormones, body composition, serum metabolic profile, levels of brain-derived neurotrophic factor (BDNF), and the association of these parameters with the clinical outcome in patients with COVID-19. We sought to examine whether obesity, sex, and age influence the adipose tissue endocrine response to the disease. Methods: This prospective study investigated 145 hospitalized patients with COVID-19. Patients were categorized based on their body mass index (BMI), sex and age, and were also classified regarding their outcome after hospitalization as: (a) Non-ICU: patients hospitalized who did not receive intensive care; (b) ICU-survivor: patients admitted to the intensive care unit and discharged; (c) ICU-death: patients who died. Blood samples were collected by the hospital staff between the first and third day of hospitalization. Serum leptin, adiponectin and BDNF concentrations, triglycerides, total cholesterol and cholesterol fractions were performed following the manufacturer's guidelines. Results: We demonstrate that BDNF levels predict intensive care (IC) need (p < 0.01). This association was found to be stronger in patients >60y (p = 0.026). Neither leptin nor adiponectin concentration was associated with IC requirement or with patient's outcome, while the BDNF/adiponectin ratio was closely associated with worsened outcomes (p < 0.01). BDNF concentration was similar between sexes, however tended to be lower in male patients (p = 0.023). In older patients, BDNF concentration was lower than that of younger patients (p = 0.020). These age and sex-specific differences should be considered when employing these potential markers for prognosis assessment. While appetite and body composition regulating hormones secreted by the white adipose tissue are not reliable predictors of disease severity, the ratio BDNF/adiponectin was indicative of patient status. Conclusion: Thus, we propose that serum BDNF content and BDNF/adiponectin ratio may serve as tools predicting worsened prognosis in COVID-19, especially for male patients.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionPontificia Universidade Católica do Paraná-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Postgraduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista (UNESP)-
Descrição: dc.descriptionCancer Metabolism Research Group LIM26-HC FMUSP University of São Paulo-
Descrição: dc.descriptionGraduate Program in Health Sciences School of Medicine Pontificia Universidade Catolica do Parana-
Descrição: dc.descriptionPolytechnic Institute of Coimbra Coimbra Health School-
Descrição: dc.descriptionLaboratory for Applied Health Research (LabinSaúde)-
Descrição: dc.descriptionDepartment of Exercise Physiology and Sports Therapy Institute of Sports Science Justus-Liebig-University Giessen-
Descrição: dc.descriptionExercise and Immunometabolism Research Group Postgraduation Program in Movement Sciences Department of Physical Education Universidade Estadual Paulista (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Nutrition-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectadiponectin-
Palavras-chave: dc.subjectadipose tissue hormones-
Palavras-chave: dc.subjectBDNF-
Palavras-chave: dc.subjectCOVID-19 severity-
Palavras-chave: dc.subjectleptin-
Título: dc.titleCOVID-19 Outcome Relates With Circulating BDNF, According to Patient Adiposity and Age-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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