Vegf expression, cellular infiltration, and intratumoral collagen levels after electroporation-based treatment of dogs with cutaneous squamous cell carcinoma

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Franca-
Autor(es): dc.contributorPaulista University—UNIP-
Autor(es): dc.creatorDos Anjos, Denner-
Autor(es): dc.creatorBueno, Cynthia-
Autor(es): dc.creatorMattos-Junior, Ewaldo-
Autor(es): dc.creatorDe Nardi, Andrigo Barboza-
Autor(es): dc.creatorFonseca-Alves, Carlos Eduardo-
Data de aceite: dc.date.accessioned2025-08-21T16:43:52Z-
Data de disponibilização: dc.date.available2025-08-21T16:43:52Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/life11121321-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223096-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223096-
Descrição: dc.descriptionCanine cutaneous squamous cell carcinoma (SCC) is the most common type of skin cancer in tropical countries and is generally associated with exposure to solar ultraviolet light. It has a low metastatic rate, and local treatments, such as electrochemotherapy (ECT), promote long-term control or even complete remission. This study aimed to evaluate pre-and post-ECT treatment expression levels of vascular endothelial growth factor (VEGF) and CD31, cellular infiltration, and intratumoral collagen levels in dogs with cutaneous SCC. A prospective nonrandomized clinical study was performed using dogs with spontaneous SCC treated with ECT. Eighteen lesions from 11 dogs were included in the study. The expression levels of VEGF and CD31; cellular infiltration; and intratumoral collagen levels, as determined by Masson’s trichrome staining, were not significantly different from pre-treatment measurements on day 21 (p > 0.05). However, among cellular infiltration, the mixed subtype was correlated with better overall survival time when compared to lymphoplasmacytic and neutrophilic infiltration (p < 0.05). In conclusion, ECT had no effect on VEGF expression, cellular infiltration, or intratumoral collagen levels in dogs with cutaneous SCC at the time of evaluation, suggesting that early and late post-ECT-treatment phases should be considered.-
Descrição: dc.descriptionDepartment of Veterinary Clinic and Surgery São Paulo State University-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Anesthesiology University of Franca-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Anesthesiology São Paulo State University—UNESP-
Descrição: dc.descriptionInstitute of Health Sciences Bauru Campus Paulista University—UNIP-
Descrição: dc.descriptionDepartment of Veterinary Clinic and Surgery São Paulo State University-
Descrição: dc.descriptionDepartment of Veterinary Surgery and Animal Anesthesiology São Paulo State University—UNESP-
Idioma: dc.languageen-
Relação: dc.relationLife-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBleomycin-
Palavras-chave: dc.subjectCutaneous carcinoma-
Palavras-chave: dc.subjectDoxorubicin-
Palavras-chave: dc.subjectElectrochemotherapy-
Palavras-chave: dc.subjectElectroporation-based treatment-
Palavras-chave: dc.subjectMasson’s trichrome-
Título: dc.titleVegf expression, cellular infiltration, and intratumoral collagen levels after electroporation-based treatment of dogs with cutaneous squamous cell carcinoma-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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