Disclosing the bioactive metabolites involved in the in vitro anthelmintic effects of salt-tolerant plants through a combined approach using PVPP and HPLC-ESI-MSn

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Algarve-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorINRAe-
Autor(es): dc.contributorUniversity of Jaén-
Autor(es): dc.contributorUniversité de Toulouse-
Autor(es): dc.creatorOliveira, Marta-
Autor(es): dc.creatorLima, Caroline Sprengel-
Autor(es): dc.creatorKetavong, Setha-
Autor(es): dc.creatorLlorent-Martínez, Eulogio J.-
Autor(es): dc.creatorHoste, Hervé-
Autor(es): dc.creatorCustódio, Luísa-
Data de aceite: dc.date.accessioned2025-08-21T20:39:58Z-
Data de disponibilização: dc.date.available2025-08-21T20:39:58Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-021-03472-9-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223086-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223086-
Descrição: dc.descriptionStrategies to reduce dependence on synthetic drugs for the treatment of gastrointestinal nematodes (GIN) infections in ruminants include the search for novel anthelmintic scaffolds on plants, yet salt-tolerant plants remain overlooked. This study aims to evaluate the in vitro anthelmintic properties of selected salt-tolerant plants against GIN, and identify the potential bioactive secondary metabolites involved. For that purpose, 80% acetone/water extracts were prepared from dried biomass of aerial organs of nine salt-tolerant plant species and tested against Haemonchus contortus and Trichostrongylus colubriformis by the Larval Exsheathment Inhibition Assay (LEIA) and Egg Hatching Inhibition Assay (EHIA). Pistacia lentiscus, Limoniatrum monopetalum, Cladium mariscus and Helychrisum italicum picardi were the most active in both GIN and life stages. To investigate the role of polyphenols in the anthelmintic activity, four selected extracts were treated with polyvinylpolypyrrolidone (PVPP), and non-treated and treated samples were further characterized by high-performance liquid chromatography with electrospray ionization mass spectrometric detection (HPLC-ESI-MSn). While polyphenols seem responsible for the EHIA properties, they are partially accountable to LEIA results. Several phenolics involved in the anthelmintic effects were identified and discussed. In sum, these species are rich sources of anthelmintic compounds and, therefore, are of major interest for nutraceutical and/or phytotherapeutic applications against GIN in ruminants.-
Descrição: dc.descriptionPartnership for Research and Innovation in the Mediterranean Area-
Descrição: dc.descriptionFundação para a Ciência e a Tecnologia-
Descrição: dc.descriptionCentre of Marine Sciences University of Algarve, Campus de Gambelas-
Descrição: dc.descriptionLaboratory of Antibiotics and Chemotherapeutics IBILCE São Paulo State University-
Descrição: dc.descriptionUMR 1225 IHAP INRAe, 23 Chemin des Capelles-
Descrição: dc.descriptionDepartment of Physical and Analytical Chemistry Faculty of Experimental Sciences University of Jaén, Campus Las Lagunillas-
Descrição: dc.descriptionENVT Université de Toulouse, 23 Chemin des Capelles-
Descrição: dc.descriptionLaboratory of Antibiotics and Chemotherapeutics IBILCE São Paulo State University-
Descrição: dc.descriptionPartnership for Research and Innovation in the Mediterranean Area: 2019-SECTION2-16-
Descrição: dc.descriptionFundação para a Ciência e a Tecnologia: CEECIND/00425/2017-
Descrição: dc.descriptionFundação para a Ciência e a Tecnologia: Multi/04326/2020-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleDisclosing the bioactive metabolites involved in the in vitro anthelmintic effects of salt-tolerant plants through a combined approach using PVPP and HPLC-ESI-MSn-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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