Approaching Genetics Through the MHC Lens: Tools and Methods for HLA Research

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversité de Nantes-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorSan Francisco-
Autor(es): dc.contributorEcole Centrale de Nantes-
Autor(es): dc.creatorDouillard, Venceslas-
Autor(es): dc.creatorCastelli, Erick C.-
Autor(es): dc.creatorMack, Steven J.-
Autor(es): dc.creatorHollenbach, Jill A.-
Autor(es): dc.creatorGourraud, Pierre-Antoine-
Autor(es): dc.creatorVince, Nicolas-
Autor(es): dc.creatorLimou, Sophie-
Data de aceite: dc.date.accessioned2025-08-21T21:36:46Z-
Data de disponibilização: dc.date.available2025-08-21T21:36:46Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-12-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fgene.2021.774916-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223075-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223075-
Descrição: dc.descriptionThe current SARS-CoV-2 pandemic era launched an immediate and broad response of the research community with studies both about the virus and host genetics. Research in genetics investigated HLA association with COVID-19 based on in silico, population, and individual data. However, they were conducted with variable scale and success; convincing results were mostly obtained with broader whole-genome association studies. Here, we propose a technical review of HLA analysis, including basic HLA knowledge as well as available tools and advice. We notably describe recent algorithms to infer and call HLA genotypes from GWAS SNPs and NGS data, respectively, which opens the possibility to investigate HLA from large datasets without a specific initial focus on this region. We thus hope this overview will empower geneticists who were unfamiliar with HLA to run MHC-focused analyses following the footsteps of the Covid-19|HLA & Immunogenetics Consortium.-
Descrição: dc.descriptionCentre de Recherche en Transplantation et Immunologie CHU Nantes Inserm Centre de Recherche en Transplantation et Immunologie Université de Nantes-
Descrição: dc.descriptionUnesp—Universidade Estadual Paulista-
Descrição: dc.descriptionDivision of Allergy Immunology and Bone Marrow Transplantation Department of Pediatrics School of Medicine University of California San Francisco-
Descrição: dc.descriptionDepartment of Neurology University of California San Francisco-
Descrição: dc.descriptionDepartment of Epidemiology and Biostatistics University of California San Francisco-
Descrição: dc.descriptionEcole Centrale de Nantes Department of Computer Sciences and Mathematics in Biology-
Descrição: dc.descriptionUnesp—Universidade Estadual Paulista-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Genetics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectassociation analysis-
Palavras-chave: dc.subjectHLA-
Palavras-chave: dc.subjectimmunogenetics-
Palavras-chave: dc.subjectimputation-
Palavras-chave: dc.subjectMajor Histocompatibility Complex (MHC)-
Título: dc.titleApproaching Genetics Through the MHC Lens: Tools and Methods for HLA Research-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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