SARS- CoV-2 infection and oxidative stress in early-onset preeclampsia

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorVenezuelan Institute for Scientific Research (IVIC)-
Autor(es): dc.contributorUniversidad de Sevilla-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Queensland-
Autor(es): dc.contributorUniversity Medical Center Groningen (UMCG)-
Autor(es): dc.contributorPontificia Universidad Católica de Chile-
Autor(es): dc.creatorMarín, Reinaldo-
Autor(es): dc.creatorPujol, Flor H.-
Autor(es): dc.creatorRojas, Deliana-
Autor(es): dc.creatorSobrevia, Luis-
Data de aceite: dc.date.accessioned2025-08-21T22:05:36Z-
Data de disponibilização: dc.date.available2025-08-21T22:05:36Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bbadis.2021.166321-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223061-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223061-
Descrição: dc.descriptionSARS-CoV-2 causes coronavirus disease 2019 (COVID-19) also in pregnant women. Infection in pregnancy leads to maternal and placental functional alterations. Pregnant women with vascular defects such as preeclampsia show high susceptibility to SARS-CoV-2 infection by undefined mechanisms. Pregnant women infected with SARS-CoV-2 show higher rates of preterm birth and caesarean delivery, and their placentas show signs of vasculopathy and inflammation. It is still unclear whether the foetus is affected by the maternal infection with this virus and whether maternal infection associates with postnatal affections. The SARS-CoV-2 infection causes oxidative stress and activation of the immune system leading to cytokine storm and next tissue damage as seen in the lung. The angiotensin-converting-enzyme 2 expression is determinant for these alterations in the lung. Since this enzyme is expressed in the human placenta, SARS-CoV-2 could infect the placenta tissue, although reported to be of low frequency compared with maternal lung tissue. Early-onset preeclampsia (eoPE) shows higher expression of ADAM17 (a disintegrin and metalloproteinase 17) causing an imbalanced renin-angiotensin system and endothelial dysfunction. A similar mechanism seems to potentially account for SARS-CoV-2 infection. This review highlights the potentially common characteristics of pregnant women with eoPE with those with COVID-19. A better understanding of the mechanisms of SARS-CoV-2 infection and its impact on the placenta function is determinant since eoPE/COVID-19 association may result in maternal metabolic alterations that might lead to a potential worsening of the foetal programming of diseases in the neonate, young, and adult.-
Descrição: dc.descriptionMinisterio de Ciencia, Tecnología e Innovación Productiva-
Descrição: dc.descriptionPontificia Universidad Católica de Chile-
Descrição: dc.descriptionFondo Nacional de Desarrollo Científico y Tecnológico-
Descrição: dc.descriptionFondo Nacional de Ciencia Tecnología e Innovación-
Descrição: dc.descriptionLaboratory of Cell Bioenergetics Center for Biophysics and Biochemistry (CBB) Venezuelan Institute for Scientific Research (IVIC), AP 21827-
Descrição: dc.descriptionLaboratory of Molecular Virology Center for Microbiology and Cell Biology (CMCB) Venezuelan Institute for Scientific Research (IVIC), AP 21827-
Descrição: dc.descriptionDepartment of Physiology Faculty of Pharmacy Universidad de Sevilla-
Descrição: dc.descriptionMedical School (Faculty of Medicine) Sao Paulo State University (UNESP)-
Descrição: dc.descriptionUniversity of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of Queensland-
Descrição: dc.descriptionDepartment of Pathology and Medical Biology Division of Pathology University of Groningen University Medical Center Groningen (UMCG)-
Descrição: dc.descriptionCellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaecology School of Medicine Faculty of Medicine Pontificia Universidad Católica de Chile-
Descrição: dc.descriptionMedical School (Faculty of Medicine) Sao Paulo State University (UNESP)-
Descrição: dc.descriptionFondo Nacional de Desarrollo Científico y Tecnológico: 1190316-
Descrição: dc.descriptionFondo Nacional de Ciencia Tecnología e Innovación: F-2005000222-
Idioma: dc.languageen-
Relação: dc.relationBiochimica et Biophysica Acta - Molecular Basis of Disease-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCOVID-19-
Palavras-chave: dc.subjectHuman-
Palavras-chave: dc.subjectPlacenta-
Palavras-chave: dc.subjectPreeclampsia-
Palavras-chave: dc.subjectPregnancy-
Título: dc.titleSARS- CoV-2 infection and oxidative stress in early-onset preeclampsia-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.