Autologous adipose-derived mesenchymal stem cells and hydroxyapatite for bone defect in rabbits

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorBioCell-
Autor(es): dc.creatorFranco, Guilherme Galhardo-
Autor(es): dc.creatorMinto, Bruno Watanabe-
Autor(es): dc.creatorde Paula Coelho, Livia-
Autor(es): dc.creatorMalard, Patricia Furtado-
Autor(es): dc.creatorCarvalho, Elizabeth Regina-
Autor(es): dc.creatorKawamoto, Fernando Yoiti Kitamura-
Autor(es): dc.creatorde Alcantara, Brenda Mendonca-
Autor(es): dc.creatorDias, Luis Gustavo Gosuen Goncalves-
Data de aceite: dc.date.accessioned2025-08-21T17:25:33Z-
Data de disponibilização: dc.date.available2025-08-21T17:25:33Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.17221/85/2020-VETMED-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/223038-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/223038-
Descrição: dc.descriptionThis study aims to evaluate the effect of autologous adipose-derived mesenchymal stem cells (AAD-MSC), with and without synthetic absorbable hydroxyapatite (HAP-91), on the bone regeneration in rabbits. Thirty-four female white New Zealand rabbits were submitted to a 10 mm distal diaphyseal radius ostectomy, divided into 3 experimental groups according to the treatment established. The bone gap was filled with 0.15 ml of a 0.9% saline solution containing two million AAD-MSC (G1), or AAD-MSC associated with HAP-91 (G2). The control group (CG) received only 0.15 ml of the 0.9% saline solution. Radiographs were made post-operatively, and after 15, 30, 45 and 90 days. Fifty percent of the samples were submitted to a histological examination at 45 days and the remaining ones at 90 days post-operatively. Radiographically, the periosteal reaction, bone callus volume and bone bridge quality were superior in G2 (P < 0.05). Histologically, the bone repair was faster and more efficient in G1 at 45 days (P < 0.05). In conclusion, AAD-MSC improved the regeneration on the experimentally induced bone defects in rabbits; however, the use of hydroxyapatite requires caution given the granulomatous reaction produced in the species.-
Descrição: dc.descriptionDepartment of Clinical and Veterinary Surgery Faculty of Agrarian and Veterinary Sciences São Paulo State University (UNESP), SP-
Descrição: dc.descriptionBioCell, DF-
Descrição: dc.descriptionDepartment of Clinical and Veterinary Surgery Faculty of Agrarian and Veterinary Sciences São Paulo State University (UNESP), SP-
Formato: dc.format38-45-
Idioma: dc.languageen-
Relação: dc.relationVeterinarni Medicina-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAdipose derived MSC-
Palavras-chave: dc.subjectCell transplantation-
Palavras-chave: dc.subjectFracture healing-
Palavras-chave: dc.subjectOryctolagus cuniculus-
Título: dc.titleAutologous adipose-derived mesenchymal stem cells and hydroxyapatite for bone defect in rabbits-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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