Ultrasonographic assessment of renal perfusion in bitches with mammary carcinoma treated with long-term carprofen

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Viçosa (UFV)-
Autor(es): dc.contributorUniversidade Federal de Santa Maria-
Autor(es): dc.creatorVargas Estrada, Cristhian Rene-
Autor(es): dc.creatorFirmo, Bruna Fernanda-
Autor(es): dc.creatorBelchior Vela, Daniele-
Autor(es): dc.creatorMaronezi, Marjury Cristina-
Autor(es): dc.creatorRamirez Uscategui, Ricardo Andrés-
Autor(es): dc.creatorGasser, Beatriz-
Autor(es): dc.creatorRossi Feliciano, Marcus Antônio-
Autor(es): dc.creatorPavan, Letícia-
Autor(es): dc.creatorNogueira Aires, Luiz Paulo-
Autor(es): dc.creatorPiovan Lima, Gabriela-
Autor(es): dc.creatorDe Nardi, Andrigo Barboza-
Data de aceite: dc.date.accessioned2025-08-21T20:09:32Z-
Data de disponibilização: dc.date.available2025-08-21T20:09:32Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-021-02781-3-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222999-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222999-
Descrição: dc.descriptionThe aim of this study was to evaluate renal hemodynamics, routine clinical and laboratory parameters used to estimate renal function, and clinical evolution during six months in bitches with mammary carcinomas that underwent mastectomy and were treated (TG) or not (CG) with carprofen for three months after surgery. Twenty-six bitches with mammary carcinoma were equally distributed into TG that received carprofen 4.4 mg/kg/day for 90 days and CG that did not receive anti-inflammatory medication. Renal artery Doppler flowmetry, contrast-enhanced ultrasound (CEUS) of renal parenchyma, haematological, biochemical and clinical analyses were obtained once a month. These data were compared between groups and time via analysis of variance (ANOVA) in a completely randomized design with repeated measures (P < 0.05). On B-mode ultrasound, the area of the renal artery was greater (P = 0.0003) in the TG. Regarding laboratory findings, haematocrit and haemoglobin were similar in both groups, showing a significant and gradual increase after three months of treatment; MCV, MHC, and MCHC were increased (P < 0.05) and lymphocyte and band counts decreased (P < 0.05) in the TG. Regarding biochemical tests, ALT was the only parameter with a significant difference, being higher (P = 0.0272) in the treated group. It can be concluded that the use of carprofen for 90 days causes minimal changes in renal perfusion, erythrocyte parameters and ALT activity, and reduces the proportion of blood inflammatory cells. Therefore, use of this medication can be carried out safely in patients who require auxiliary cancer treatment.-
Descrição: dc.descriptionFaculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista “Júlio de Mesquita Filho”–Jaboticabal-
Descrição: dc.descriptionUniversidade Federal dos Vales do Jequitinhonha e Mucuri–UFVJM-
Descrição: dc.descriptionUniversidade Federal de Santa Maria-
Descrição: dc.descriptionFaculdade de Ciências Agrárias e Veterinárias Universidade Estadual Paulista “Júlio de Mesquita Filho”–Jaboticabal-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleUltrasonographic assessment of renal perfusion in bitches with mammary carcinoma treated with long-term carprofen-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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