Multiple Risk Factors for Heart Disease: A Challenge to the Ethnopharmacological Use of Croton urucurana Baill.

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Autor(es): dc.contributorParanaense University-
Autor(es): dc.contributorFederal University of Grande Dourados-
Autor(es): dc.contributorPequeno Príncipe Faculty-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorPost-Graduate Program in Animal Science with Emphasis on Bioactive Products-
Autor(es): dc.creatorZago, Priscila Megda João Job-
Autor(es): dc.creatorSilva, Gustavo Ratti Da-
Autor(es): dc.creatorAmaral, Eduarda Carolina-
Autor(es): dc.creatorBarboza, Lorena Neris-
Autor(es): dc.creatorBraga, Fernanda De Abreu-
Autor(es): dc.creatorLorençone, Bethânia Rosa-
Autor(es): dc.creatorMarques, Aline Aparecida Macedo-
Autor(es): dc.creatorMoreno, Karyne Garcia Tafarelo-
Autor(es): dc.creatorLeite, Patrícia Regina Terço-
Autor(es): dc.creatorVeiga, Alan De Almeida-
Autor(es): dc.creatorSouza, Lauro Mera De-
Autor(es): dc.creatorSouza, Roosevelt Isaias Carvalho-
Autor(es): dc.creatorSantos, Ariany Carvalho Dos-
Autor(es): dc.creatorRibeiro-Paes, João Tadeu-
Autor(es): dc.creatorGasparotto Junior, Arquimedes-
Autor(es): dc.creatorLívero, Francislaine Aparecida Dos Reis-
Data de aceite: dc.date.accessioned2025-08-21T19:48:58Z-
Data de disponibilização: dc.date.available2025-08-21T19:48:58Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1155/2021/6580458-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222962-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222962-
Descrição: dc.descriptionCroton urucurana Baill. is a native Brazilian tree, popularly known as sangra-d'águaor sangue-de-dragão,based on the red resinous sap of the trunk. Its use has been transmitted through generations based on popular tradition that attributes analgesic, anti-inflammatory, and cardioprotective properties to the tree. However, its cardioprotective effects have not yet been scientifically investigated. Thus, the present study investigated the pharmacological response to an ethanol-soluble fraction from the leaves of C. urucurana in Wistar rats exposed to smoking and dyslipidemia, two important cardiovascular risk factors. The extract was evaluated by high-performance liquid chromatography. Wistar rats received a 0.5% cholesterol-enriched diet and were exposed to cigarette smoke (9 cigarettes/day for 10 weeks). During the last 5 weeks, the animals were orally treated with vehicle (negative control group), C. urucurana extract (30, 100, and 300 mg/kg), or simvastatin (2.5 mg/kg) + enalapril (15 mg/kg). One group of rats that was not exposed to these risk factors was also evaluated (basal group). Electrocardiograms and systolic, diastolic, and mean blood pressure were measured. Blood was collected to measure total cholesterol, triglycerides, urea, and creatinine. The heart and kidneys were collected and processed for oxidative status and histopathological evaluation. The phytochemical analysis revealed different classes of flavonoids and condensed tannins. The model induced dyslipidemia and cardiac and renal oxidative stress and increased levels of urea and creatinine in the negative control group. Treatment with the C. urucurana extract (300 mg/kg) and simvastatin + enalapril decreased cholesterol and triglyceride levels. In contrast to simvastatin + enalapril treatment, the C. urucurana extract exerted cardiac and renal antioxidant effects. No alterations of electrocardiograms, blood pressure, or histopathology were observed between groups. These findings indicate that C. urucurana exerts lipid-lowering, renal, and cardioprotective effects against oxidative stress in a preclinical model of multiple risk factors for heart disease.-
Descrição: dc.descriptionLaboratory of Preclinical Research of Natural Products Post-Graduate Program in Medicinal Plants and Phytotherapeutics in Basic Attention Paranaense University-
Descrição: dc.descriptionLaboratory of Preclinical Research of Natural Products Post-Graduate Program in Animal Science with Emphasis on Bioactive Products Paranaense University-
Descrição: dc.descriptionLaboratory of Cardiovascular Pharmacology Faculty of Health Sciences Federal University of Grande Dourados-
Descrição: dc.descriptionInstitute of Research Pelé Pequeno Príncipe Pequeno Príncipe Faculty-
Descrição: dc.descriptionLaboratory of Histology Faculty of Health Sciences Federal University of Grande Dourados-
Descrição: dc.descriptionLaboratory of Genetics and Cell Therapy São Paulo State University-
Descrição: dc.descriptionLaboratory of Preclinical Research of Natural Products Post-Graduate Program in Medicinal Plants and Phytotherapeutics in Basic Attention Post-Graduate Program in Animal Science with Emphasis on Bioactive Products-
Descrição: dc.descriptionLaboratory of Genetics and Cell Therapy São Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationEvidence-based Complementary and Alternative Medicine-
???dc.source???: dc.sourceScopus-
Título: dc.titleMultiple Risk Factors for Heart Disease: A Challenge to the Ethnopharmacological Use of Croton urucurana Baill.-
Tipo de arquivo: dc.typelivro digital-
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