A New Crystalline Ketoprofen Sodium Salt: Solid-State Characterization, Solubility, and Stability

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Alfenas (UNIFAL-MG)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorde Oliveira Junior, Homero-
Autor(es): dc.creatorBorges, Bruno Arantes-
Autor(es): dc.creatorBarbosa, Thulio Wliandon Lemos-
Autor(es): dc.creatorBatista, Ataislaine-
Autor(es): dc.creatorBraga, Maria Teresa Leite-
Autor(es): dc.creatorde Araújo, Magali Benjamim-
Autor(es): dc.creatorBonfilio, Rudy-
Data de aceite: dc.date.accessioned2025-08-21T20:19:12Z-
Data de disponibilização: dc.date.available2025-08-21T20:19:12Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.xphs.2021.11.011-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222953-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222953-
Descrição: dc.descriptionKetoprofen (KTP) is an Active Pharmaceutical Ingredient (API) that has low solubility in aqueous solvents. The use of KTP salts has attracted attention due to its improvements in terms of solubility, tolerability, higher rate and extent of absorption, and faster onset of the therapeutic effect. In this work, a crystalline KTP sodium salt (coded as KTP-Na) was successfully obtained and widely characterized by X-ray powder diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), solubility and accelerated stability studies. XRD results showed that KTP-Na is not yet reported in the literature. Moreover, FTIR, DSC and TGA were useful for differentiation of KTP-Na from the KTP commercialized form (coded as KTP-R1). The solubility of KTP-Na in water was about 80 times greater than the KTP-R1. However, KTP-Na showed lower physical stability in storage conditions at 40 ± 2°C/ 75% ± 5% RH when compared to KTP-R1, which was shown to be related to a high hygroscopicity of KTP-Na. Therefore, due to its higher solubility, KTP-Na may be a viable alternative for use in solid dosage forms. However, the presence of moisture must be strictly controlled to avoid water absorption and consequent amorphization.-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences Federal University of Alfenas (UNIFAL-MG)-
Descrição: dc.descriptionInstitute of Chemistry Federal University of Alfenas (UNIFAL-MG)-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences São Paulo State University (UNESP-SP)-
Descrição: dc.descriptionFaculty of Pharmaceutical Sciences São Paulo State University (UNESP-SP)-
Idioma: dc.languageen-
Relação: dc.relationJournal of Pharmaceutical Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectFourier transform infrared spectroscopy-
Palavras-chave: dc.subjectKetoprofen sodium-
Palavras-chave: dc.subjectSolid-state characterization-
Palavras-chave: dc.subjectSolubility-
Palavras-chave: dc.subjectStability-
Palavras-chave: dc.subjectThermal analysis-
Palavras-chave: dc.subjectX-ray powder diffraction-
Título: dc.titleA New Crystalline Ketoprofen Sodium Salt: Solid-State Characterization, Solubility, and Stability-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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