Crotalphine attenuates pain and neuroinflammation induced by experimental autoimmune encephalomyelitis in mice

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Autor(es): dc.contributorButantan Institute-
Autor(es): dc.contributorSanta Casa of Sao Paulo-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorHospital Sírio-Libanês-
Autor(es): dc.creatorGiardini, Aline C.-
Autor(es): dc.creatorEvangelista, Bianca G.-
Autor(es): dc.creatorSant’anna, Morena B.-
Autor(es): dc.creatorMartins, Barbara B.-
Autor(es): dc.creatorLancellotti, Carmen L. P.-
Autor(es): dc.creatorCiena, Adriano P.-
Autor(es): dc.creatorChacur, Marucia-
Autor(es): dc.creatorPagano, Rosana L.-
Autor(es): dc.creatorRibeiro, Orlando G.-
Autor(es): dc.creatorZambelli, Vanessa O.-
Autor(es): dc.creatorPicolo, Gisele-
Data de aceite: dc.date.accessioned2025-08-21T20:37:11Z-
Data de disponibilização: dc.date.available2025-08-21T20:37:11Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/toxins13110827-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222926-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222926-
Descrição: dc.descriptionMultiple sclerosis (MS) is a demyelinating disease of inflammatory and autoimmune origin, which induces sensory and progressive motor impairments, including pain. Cells of the immune system actively participate in the pathogenesis and progression of MS by inducing neuroinflamma-tion, tissue damage, and demyelination. Crotalphine (CRO), a structural analogue to a peptide firstly identified in Crotalus durissus terrificus snake venom, induces analgesia by endogenous opioid release and type 2 cannabinoid receptor (CB2) activation. Since CB2 activation downregulates neuroinflam-mation and ameliorates symptoms in mice models of MS, it was presently investigated whether CRO has a beneficial effect in the experimental autoimmune encephalomyelitis (EAE). CRO was administered on the 5th day after immunization, in a single dose, or five doses starting at the peak of disease. CRO partially reverted EAE-induced mechanical hyperalgesia and decreased the severity of the clinical signs. In addition, CRO decreases the inflammatory infiltrate and glial cells activation followed by TNF-α and IL-17 downregulation in the spinal cord. Peripherally, CRO recovers the EAE-induced impairment in myelin thickness in the sciatic nerve. Therefore, CRO interferes with central and peripheral neuroinflammation, opening perspectives to MS control.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionLaboratory of Pain and Signaling Butantan Institute-
Descrição: dc.descriptionDepartment of Pathological Sciences Medical Science School Santa Casa of Sao Paulo-
Descrição: dc.descriptionLaboratory of Morphology Institute of Biosciences São Paulo State University-
Descrição: dc.descriptionLaboratory of Functional Neuroanatomy of Pain Instituto de Ciências Biomédicas Universidade de Sao Paulo-
Descrição: dc.descriptionLaboratory of Neuroscience Hospital Sírio-Libanês-
Descrição: dc.descriptionLaboratory of Immunogenetics Butantan Institute-
Descrição: dc.descriptionLaboratory of Morphology Institute of Biosciences São Paulo State University-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2013/07467-1-
Descrição: dc.descriptionFAPESP: 2015/01254-1-
Descrição: dc.descriptionCNPq: 467211/2014-0-
Idioma: dc.languageen-
Relação: dc.relationToxins-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectGlial cells-
Palavras-chave: dc.subjectIL-17-
Palavras-chave: dc.subjectInflammation-
Palavras-chave: dc.subjectNeurodegeneration-
Palavras-chave: dc.subjectNeurodegenerative disease-
Título: dc.titleCrotalphine attenuates pain and neuroinflammation induced by experimental autoimmune encephalomyelitis in mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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