Phenothiazinium dyes for photodynamic treatment present lower environmental risk compared to a formulation of trifloxystrobin and tebuconazole

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorLaboratory of Mutagenesis-
Autor(es): dc.contributorDivisão de Laboratório de Ribeirão Preto-
Autor(es): dc.contributorFund for Citrus Protection-
Autor(es): dc.contributorLiverpool John Moores University-
Autor(es): dc.creatorAndrade, Gabriela Carvalho-
Autor(es): dc.creatorBrancini, Guilherme Thomaz Pereira-
Autor(es): dc.creatorAbe, Flávia Renata-
Autor(es): dc.creatorde Oliveira, Danielle Palma-
Autor(es): dc.creatorNicolella, Heloiza Diniz-
Autor(es): dc.creatorTavares, Denise Crispim-
Autor(es): dc.creatorMicas, André Fernando Ditondo-
Autor(es): dc.creatorSavazzi, Eduardo Angelino-
Autor(es): dc.creatorSilva-Junior, Geraldo José-
Autor(es): dc.creatorWainwright, Mark-
Autor(es): dc.creatorBraga, Gilberto Úbida Leite-
Data de aceite: dc.date.accessioned2025-08-21T18:43:16Z-
Data de disponibilização: dc.date.available2025-08-21T18:43:16Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jphotobiol.2021.112365-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222907-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222907-
Descrição: dc.descriptionThe widespread use of conventional chemical antifungal agents has led to worldwide concern regarding the selection of resistant isolates. In this scenario, antimicrobial photodynamic treatment (APDT) has emerged as a promising alternative to overcome this issue. The technique is based on the use of a photosensitizer (PS) and light in the presence of molecular oxygen. Under these conditions, the PS generates reactive oxygen species which damage the biomolecules of the target organism leading to cell death. The great potential of APDT against plant-pathogenic fungi has already been reported both in vitro and in planta, indicating this control measure has the potential to be widely used in crop plants. However, there is a lack of studies on environmental risk with ecotoxicological assessment of PSs used in APDT. Therefore, this study aimed to evaluate the environmental toxicity of four phenothiazinium PSs: i) methylene blue (MB), ii) new methylene blue N (NMBN), iii) toluidine blue O (TBO), and iv) dimethylmethylene blue (DMMB) and also of the commercial antifungal NATIVO®, a mixture of trifloxystrobin and tebuconazole. The experiments were performed with Daphnia similis neonates and zebrafish embryos. Our results showed that the PSs tested had different levels of toxicity, with MB being the less toxic and DMMB being the most. Nonetheless, the environmental toxicity of these PSs were lower when compared to that of NATIVO®. Furthermore, estimates of bioconcentration and of biotransformation half-life indicated that the PSs are environmentally safer than NATIVO®. Taken together, our results show that the toxicity associated with phenothiazinium PSs would not constitute an impediment to their use in APDT. Therefore, APDT is a promising approach to control plant-pathogenic fungi with reduced risk for selecting resistant isolates and lower environmental impacts when compared to commonly used antifungal agents.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionUniversity of São Paulo (USP) School of Pharmaceutical Sciences of Ribeirão Preto-
Descrição: dc.descriptionNational Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) São Paulo State University (UNESP) Institute of Chemistry-
Descrição: dc.descriptionUniversity of Franca Laboratory of Mutagenesis-
Descrição: dc.descriptionCompanhia Ambiental do Estado de São Paulo (CETESB) Divisão de Laboratório de Ribeirão Preto-
Descrição: dc.descriptionFund for Citrus Protection, Fundecitrus-
Descrição: dc.descriptionSchool of Pharmacy & Biomolecular Sciences Liverpool John Moores University-
Descrição: dc.descriptionNational Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) São Paulo State University (UNESP) Institute of Chemistry-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionCNPq: 165191/2020–1-
Descrição: dc.descriptionFAPESP: 2014/50945–4-
Descrição: dc.descriptionFAPESP: 2016/11386–5-
Descrição: dc.descriptionFAPESP: 2016/24269–7-
Descrição: dc.descriptionFAPESP: 2018/06945–0-
Descrição: dc.descriptionFAPESP: 2018/24298–2-
Descrição: dc.descriptionCNPq: 307738/2018–3-
Descrição: dc.descriptionCNPq: 425998/2018–5-
Descrição: dc.descriptionCNPq: 465571/2014–0-
Idioma: dc.languageen-
Relação: dc.relationJournal of Photochemistry and Photobiology B: Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEcotoxicity-
Palavras-chave: dc.subjectFungicides-
Palavras-chave: dc.subjectPhotodynamic treatment-
Palavras-chave: dc.subjectPhotosensitizers-
Palavras-chave: dc.subjectPollutants-
Título: dc.titlePhenothiazinium dyes for photodynamic treatment present lower environmental risk compared to a formulation of trifloxystrobin and tebuconazole-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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