Physicochemical and biological properties of new tricalcium silicate-based repair material doped with fluoride ions and zirconium oxide as radiopacifier

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCampi, Lívia Bueno-
Autor(es): dc.creatorTorres, Fernanda Ferrari Esteves-
Autor(es): dc.creatorRodrigues, Elisandra Márcia-
Autor(es): dc.creatorGuerreiro-Tanomaru, Juliane Maria-
Autor(es): dc.creatorTanomaru-Filho, Mário-
Data de aceite: dc.date.accessioned2025-08-21T21:08:21Z-
Data de disponibilização: dc.date.available2025-08-21T21:08:21Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/jbm.b.34966-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222905-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222905-
Descrição: dc.descriptionThis study evaluated the physicochemical and biological properties of novel reparative materials composed of pure tricalcium silicate (Ca3SiO5), Ca3SiO5 doped with fluoride ions (Ca3SiO5-F) and their association with ZrO2 (Ca3SiO5 + ZrO2, Ca3SiO5-F + ZrO2), in comparison with Biodentine (BIO). Setting time radiopacity, pH, solubility, and dimensional change were evaluated based on ISO 6876 Standard. Volumetric change and flow/filling were assessed by microcomputed tomography (micro-CT). Biological properties were evaluated by the MTT assay 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide), Neutral Red (NR), cell migration, alkaline phosphatase activity (ALP), and Alizarin Red Staining (ARS) assays. Statistical analysis was performed by ANOVA, Tukey, or Bonferroni tests (α =.05). Ca3SiO5-F + ZrO2 had higher radiopacity, shorter setting time, and lower solubility and volumetric loss than BIO (p <.05). Ca3SiO5-F + ZrO2 had flow and filling capacity similar to BIO (p >.05). All the cements evaluated had an alkaline pH. Ca3SiO5-F + ZrO2 demonstrated cell viability similar to negative control (p >.05), increase in ALP activity in 7 days, mineralized nodule production in 21 days and repair capacity according to cell migration. In conclusion, Ca3SiO5-F + ZrO2 had adequate setting time, radiopacity, solubility, and dimensional change. This material presented low volumetric change besides flow and filling capacity in micro-CT assessment. In addition, Ca3SiO5-F + ZrO2 was biocompatible and bioactive, suggesting its use as reparative material.-
Descrição: dc.descriptionDepartment of Restorative Dentistry School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Restorative Dentistry School of Dentistry São Paulo State University (UNESP)-
Formato: dc.format862-870-
Idioma: dc.languageen-
Relação: dc.relationJournal of Biomedical Materials Research - Part B Applied Biomaterials-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectbiological properties-
Palavras-chave: dc.subjectcalcium silicate-
Palavras-chave: dc.subjectchemical properties-
Palavras-chave: dc.subjectfluoride-
Palavras-chave: dc.subjectphysical properties-
Título: dc.titlePhysicochemical and biological properties of new tricalcium silicate-based repair material doped with fluoride ions and zirconium oxide as radiopacifier-
Tipo de arquivo: dc.typelivro digital-
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